Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Exposure Controls/Personal Protection Accidental Release Measures Stability and Reactivity Fire Fighting Measures
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Acrivastine(87848-99-5)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Exposure Controls/Personal Protection Accidental Release Measures Stability and Reactivity Fire Fighting Measures

Product Identification

Product Name
Acrivastine
Synonyms
(E)-3-[6-[(E)-1-(4-Methylphenyl)-3-pyrrolidin-1-yl-prop-1-enyl]pyridin-2-yl]prop-2-enoic acid
CAS
87848-99-5
Formula
C22H24N2O2
Molecular Weight
348.44
Merck
12,129

Physical and Chemical Properties

Solubility in water
Insoluble
Vapor Pressure
3.7E-13 (25 C)
Density
1.17 g/cm3 (20 C)
pKa/pKb
1.99 (pKa)
Partition Coefficient
4.55
Usage
This material is a histamine antagonist (h1 sub-type). It is an agent intended for the treatment of allergic rhinitis.

First Aid Measures

Ingestion
Never attempt to induce vomiting. Do not attempt to give any solid or liquid by mouth if the exposed subject is unconscious or semi-conscious. Wash out the mouth with water. If the exposed subject is fully conscious, give plenty of water to drink. Obtain medical attention.
Inhalation
Physical form suggests that risk of inhalation exposure is negligible.
Skin
Using appropriate personal protective equipment, remove contaminated clothing and flush exposed area with large amounts of water. Obtain medical attention if skin reaction occurs, which may be immediate or delayed.
Eyes
Wash immediately with clean and gently flowing water. Continue for at least 15 minutes. Obtain medical attention.

Handling and Storage

Storage
No storage requirements necessary for occupational hazards. Follow product information storage instructions to maintain efficacy.

Exposure Controls/Personal Protection

Personal Protection
Wear approved safety glasses with side shields if eye contact is possible.
Exposure Effects
Exposure might occur via ingestion; skin; eyes. Possible effects of overexposure in the workplace include: sedation; irritation; swelling; redness; itching; pain.

Accidental Release Measures

Small spills/leaks
Collect and place it in a suitable, properly labeled container for recovery or disposal. Water can be used for clean-up and decontamination operations

Stability and Reactivity

Stability
Stable at normal temperatures and pressures.

Fire Fighting Measures

Fire Potential
Expected to be non-combustible.
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