Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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Diprophylline(479-18-5)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
Diprophylline
Synonyms
7-(2,3-Dihydroxypropyl)-1,3-dimethylpurine-2,6-dione
AFI-Phyllin
Aristophyllin
Astmamasit
Astrophyllin
Dyphylline
CAS
479-18-5
Formula
C10H14N4O4
Molecular Weight
254.25
EINECS
207-526-1
RTECS
XH5100000
RTECS Class
Drug
Merck
12,3529
Beilstein/Gmelin
284563
Beilstein Reference
5-26-14-00070

Physical and Chemical Properties

Appearance
White powder.
Solubility in water
330 g/L
Melting Point
155 - 157
Boiling Point
590
Vapor Pressure
1E-14 (25 C)
Density
1.18 g/cm3
pKa/pKb
13.66 (pKa)
Partition Coefficient
-1.12
Heat Of Vaporization
92.5 kJ/mol
Usage
Medication.
Refractive Index
1.5403 (172 C)

First Aid Measures

Ingestion
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Inhalation
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Skin
May cause skin irritation.
Eyes
May cause eye irritation.
Ingestion
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.

Exposure Controls/Personal Protection

Personal Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Exposure Effects
The toxicological properties of this material have not been investigated.

Fire Fighting Measures

Flash Point
310
Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Accidental Release Measures

Small spills/leaks
Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Incompatibilities
Oxidizing agents.
Stability
Stable under normal temperatures and pressures.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
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