Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information Hazards Identification
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2-(p-Aminobenzenesulfonamido)thiazole(72-14-0)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity Transport Information Hazards Identification

Product Identification

Product Name
2-(p-Aminobenzenesulfonamido)thiazole
Synonyms
1,6-Dehydro-6-chlororetroprogesterone
2-(p-Aminobenzenesulfonamido)thiazole
2-(p-Aminobenzenesulphonamido)thiazole
4-Amino-n-2-thiazolylbenzenesulfonamide
6-Chloro-1,6-dehydroretroprogesterone
Azoquimiol
Azoseptale
Pregna-1,4,6-triene-3,20-dione, 6-chloro-, (9b,10a)-
Retroid
Ro 4-8347
CAS
5192-84-7
CAS
72-14-0
Formula
C21H25ClO2
Formula
C9H9N3O2S2
Molecular Weight
255.32
Molecular Weight
344.88
EINECS
200-771-5
EINECS
225-978-8
RTECS
WP2360000
RTECS Class
Tumorigen; Mutagen; Reproductive Effector; Human Data
Merck
12,9115
Merck
12,9717
Beilstein/Gmelin
226178
Beilstein Reference
4-27-00-04623

Physical and Chemical Properties

Appearance
White crystalline powder.
Solubility in water
Slightly soluble
Solubility in water
1.9 mg/L (25 C)
Melting Point
199 - 202
Boiling Point
479
Boiling Point
480
Vapor Pressure
2.5E-9 (25 C)
Vapor Pressure
2E-9 (25 C)
Density
1.20 g/cm3 (20 C)
Density
1.61 g/cm3
pKa/pKb
7.24 (pKa)
Partition Coefficient
4.27 (25 C)
Partition Coefficient
.05
Heat Of Vaporization
74.28 kJ/mol
Heat Of Vaporization
74.4 kJ/mol
Usage
Medication (vet).
Refractive Index
1.674

First Aid Measures

Ingestion
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
Inhalation
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
Skin
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
Eyes
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.

Handling and Storage

Storage
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Handling
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Exposure Controls/Personal Protection

Personal Protection
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
Respirators
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Exposure Effects
headache, depression, and hallucinations have been reported with therapeutic use of sulfonamides. Coma and seizures were reported following a large overdose of sulfasalazine in one patient. Tremor occurred in one patient following a fixed-dose combination of trimethoprim/sulfamethoxazole.

Fire Fighting Measures

Flash Point
201
Flash Point
244
Fire Fighting
Fires involving this compound should be controlled with a dry chemical, carbon dioxide or halon extinguisher.

Accidental Release Measures

Small spills/leaks
Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Stability and Reactivity

Stability
No data.

Transport Information

HS Code
2935 00 90

Hazards Identification

Ingestion
Nausea and vomiting are likely to occur.
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