Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Accidental Release Measures Stability and Reactivity Fire Fighting Measures
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2-Chloro-2'-deoxyadenosine(4291-63-8)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Accidental Release Measures Stability and Reactivity Fire Fighting Measures

Product Identification

Product Name
2-Chloro-2'-deoxyadenosine
Synonyms
2-CdA
2-Chloro-2'-deoxyadenosine
2-Chloro-6-amino-9-(2-deoxy-b-D-erythro-pentofuranosyl)purine
2-Chlorodeoxyadenosine
Cladribine
Leustatin
CAS
4291-63-8
Formula
C10H12ClN5O3
Molecular Weight
285.69
RTECS
AU7357560
Merck
12,2397
Beilstein/Gmelin
624220

Physical and Chemical Properties

Appearance
White solid.
Solubility in water
Insoluble
Melting Point
220
Vapor Pressure
4.0E-15 (25 C)
Density
2.03 g/cm3 (20 C)
pKa/pKb
12.41 (pKb)
Partition Coefficient
.02
Usage
A drug commonly used to treat hairy cell leukemia.

First Aid Measures

Ingestion
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband.
Inhalation
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
Skin
In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.
Eyes
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention.

Handling and Storage

Storage
Keep container tightly closed, in a cool, well-ventilated area. Do not store above 4 C.

Hazards Identification

Skin
Hazardous in case of skin contact (irritant, permeator). Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering.
EC Risk Phrase
R: 20/21/22 36/37/38 40
EC Safety Phrase
S: 22 24/25 26 36/37/39 45

Exposure Controls/Personal Protection

Personal Protection
Impervious gloves, chemical safety goggles, lab coat.
Exposure Effects
May be harmful if inhaled, absorbed through the skin or swallowed. May cause irritation of the respiratory tract, eyes and skin. May cause damage to the kidneys, liver, heart, GI tract, eyes, central nervous system. May cause birth defects based on animal data.

Accidental Release Measures

Small spills/leaks
Use appropriate tools to put the spilled solid into a waste disposal container. Finish cleaning by spreading water on the contaminated surface.

Stability and Reactivity

Incompatibilities
Oxidizing agents.

Fire Fighting Measures

Fire Potential
May be combustible at high temperature. Extinguish with dry chemical powder, water spray, fog or foam. Do not use water jet. Wear positive pressure SCBA and full turnout gear.
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