Cladribine
4291-63-8 Basic informationMore
- Product Name:Cladribine
- Synonyms: 2-chlorodeoxyadenosine Biodribin Cladarabine Jk 6251 NSC 105014 (2R,3S,5R)-5-(6-aMino-2-chloro-9H-purin-9-yl)-2-(hydroxyMethyl)oxolan-3-ol Cladribine API 2-Chloro-2'-deoxyadenosine 2-Chloro-9-(2-deoxy-beta-D-arabinofuranosyl)adenine CdA
- CAS:4291-63-8
- MF:C10H12ClN5O3
- MW:285.69
- EINECS:636-978-6
- Mol File:4291-63-8.mol
-
USE
Cladribine, an adenosine deaminase inhibitor, was introduced in the United States as a single intravenous treatment for hairy cell leukemia. The incorporation of a chlorine atom at the 2-position of deoxyadenosine renders cladribine more resistant to enzymatic attack by adenosine deaminase, resulting in a more prolonged cytotoxic effect. Cladribine efficiently crosses lymphocyte and monocyte cell membranes and is metabolized in cells to the biologically active triphosphate, which inhibits DNA synthesis. While most antineoplastic drugs are active primarily against dividing cells, cladribine destroys both resting and proliferating cells. Its potential uses in the treatment of autoimmune hemolytic anemia, multiple sclerosis, chronic lymphocytic leukemia and various lymphomas have also been evaluated.
Lastest Price from Cladribine manufacturers
- Cladribine
-
- US $0.00 /KG
- CAS:4291-63-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500000kg
- 2024-11-01
- Cladribine
-
- US $145.00-0.00/g
- CAS:4291-63-8
- Min. Order: 1g
- Purity: 98%+
- Supply Ability: 100kgs
- 2024-11-01
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- Company Name:Wuhan Biocause Pharmaceutical Development Co., Ltd..
- Tel:027-84222527， 13774034449
- Products Intro:Product Name:Cladribine
CAS:4291-63-8
Purity:EP/USP Package:100g/bottle,价格面议 More... - CB Index:58
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- Company Name:RSJ Biotech Ltd.
- Tel:189-13120456 13962152618
- Products Intro:Product Name:Cladribine
CAS:4291-63-8
Purity:单杂小于0.1%,纯度大于99.8%HPLC Package:10g/RMB 800;100g - CB Index:58
- Related Information:Catalog(31)
- Company Name:J & K SCIENTIFIC LTD.
- Tel:010-82848833 400-666-7788
- Products Intro:Product Name:2-Chloro-2'-deoxyadenosine, 99%
CAS:4291-63-8
Purity:99% Package:100MG;25MG More... - CB Index:76
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- Company Name:Meryer (Shanghai) Chemical Technology Co., Ltd.
- Tel:021-61259108 18621169109
- Products Intro:Product Name:Cladribine
CAS:4291-63-8
Purity:>98.0%(LC) Package:50Mg Remarks:C2499 More... - CB Index:62
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- Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel:821-50328103-801 18930552037
- Products Intro:Product Name:Cladribine
CAS:4291-63-8
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g More... - CB Index:69
- Related Information:Catalog(15839)
- Company Name:Hongene Biotech Corporation
- Tel:021-64757213
- Products Intro:Product Name:2-Cl-dA; Cladribine/2-Cl-deoxyadenosine
CAS:4291-63-8
Purity:98% HPLC Package:G; KG More... - CB Index:61
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- Company Name:Chembest Research Laboratories Limited
- Tel:+86-21-20908456
- Products Intro:Product Name:Cladribine
CAS:4291-63-8
Remarks:C13488 More... - CB Index:61
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- Company Name:TCI (Shanghai) Development Co., Ltd.
- Tel:021-67121386
- Products Intro:Product Name:Cladribine
CAS:4291-63-8
Purity:98.0% LC Package:50MG More... - CB Index:81
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