Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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(+)-Panthenol(81-13-0)

Supplier Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
(+)-Panthenol
Synonyms
(2R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
(R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
Dexpanthenol
CAS
81-13-0
Formula
C9H19NO4
Molecular Weight
205.25
EINECS
201-327-3
RTECS
ES4316000
RTECS Class
Drug; Primary Irritant
Merck
13,2964
Beilstein/Gmelin
1724947
Beilstein Reference
4-04-00-01652

Physical and Chemical Properties

Appearance
Odorless, colorless, viscous liquid.
Solubility in water
Very soluble
Melting Point
35 - 46
Boiling Point
484
Vapor Pressure
2E-11 (25 C)
Density
1.1 g/cm3 (20 C)
pKa/pKb
13.03 (pKa)
Partition Coefficient
-1.53
Heat Of Vaporization
86.3 kJ/mol
Usage
Provitamin b5 for cosmetic and pharmaceutical preparations.
Vapor Density
2.6
Refractive Index
1.4935 (20 C)

First Aid Measures

Ingestion
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Skin
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage
Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C). Store protected from moisture.
Handling
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.

Hazards Identification

Inhalation
Causes respiratory tract irritation. Can produce delayed pulmonary edema.
Skin
Causes skin irritation.
Eyes
Causes eye irritation. May cause chemical conjunctivitis.
Ingestion
May cause gastrointestinal irritation with nausea, vomiting and diarrhea.

Exposure Controls/Personal Protection

Personal Protection
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
Exposure Effects
Effects may be delayed.

Fire Fighting Measures

Flash Point
246
Autoignition
385
Fire Fighting
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Upper exp. limit
14.4
Lower exp. limit
2.4
Fire Potential
Combustible.

Accidental Release Measures

Small spills/leaks
Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Provide ventilation.

Stability and Reactivity

Incompatibilities
Moisture, strong oxidizing agents.
Stability
Stable at room temperature in closed containers under normal storage and handling conditions.
Decomposition
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
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