Supplier Product Identification Physical and Chemical Properties Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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Sirolimus(53123-88-9)

Supplier Product Identification Physical and Chemical Properties Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity

Product Identification

Product Name
Sirolimus
Synonyms
(-)-Rapamycin
Antibiotic AY-22989
AY-22989
NSC-226080
SILA-9268A
Sirolimus
CAS
53123-88-9
Formula
C51H79NO13
Molecular Weight
914.19
RTECS
VE6250000
Merck
12,8288
Beilstein/Gmelin
5848501
Beilstein Reference
6-27

Physical and Chemical Properties

Appearance
White to off-white powder.
Solubility in water
Insoluble
Melting Point
183 - 184
Density
1.18 g/cm3
pKa/pKb
10.40 (pKa)
Partition Coefficient
3.58
Usage
Tool for immunochemistry.

Handling and Storage

Storage
Store solid and solutions at -20 ºC

Hazards Identification

Inhalation
If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
Skin
Flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
Eyes
Check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
Ingestion
Wash out mouth with copious amounts of water; call a physician

Exposure Controls/Personal Protection

Personal Protection
Protective clothing, heavy rubber gloves, chemical safety goggles.
Respirators
NIOSH/MSHA-approved respirator.
Exposure Effects
Potent immunosuppresent; may cause irritation to eyes, skin, mucous membranes.

Fire Fighting Measures

Fire Fighting
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam. Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks
Absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol.

Stability and Reactivity

Stability
Stable if stored as directed.
Incompatibilities
Strong oxidizing agents.
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