Technical Data Sheet (TDS)
Yohimbine Hydrochloride
CAS No.: 65-19-0
Molecular Formula: C₂₁H₂₇ClN₂O₃
Molecular Weight: 390.91
EINECS No.: 200-600-4
1. Product Description
Yohimbine Hydrochloride is an indole alkaloid extracted from the bark of Pausinystalia yohimbe (commonly known as Yohimbe tree).
It appears as a white or almost white crystalline powder, soluble in water and ethanol.
Yohimbine HCl is widely used in pharmaceutical, nutraceutical, and industrial research fields due to its pharmacological activity as an α2-adrenergic receptor antagonist.
2. Chemical Information
| Item | Description |
|---|
| Chemical Name | Yohimbine Hydrochloride |
| Synonyms | Yohimbine HCl, α-Yohimbine, Corynine Hydrochloride |
| CAS No. | 65-19-0 |
| Molecular Formula | C₂₁H₂₇ClN₂O₃ |
| Molecular Weight | 390.91 g/mol |
| Appearance | White or almost white crystalline powder |
| Solubility | Freely soluble in water and ethanol |
| Odor | Characteristic |
| Taste | Slightly bitter |
3. Typical Technical Specifications
| Index | Specification |
|---|
| Appearance | White or almost white crystalline powder |
| Identification | Positive |
| Assay (HPLC) | ≥ 98.0% |
| Moisture | ≤ 2.0% |
| Ash | ≤ 0.5% |
| Heavy Metals | ≤ 10 ppm |
| Lead (Pb) | ≤ 2 ppm |
| Arsenic (As) | ≤ 2 ppm |
| Cadmium (Cd) | ≤ 1 ppm |
| Mercury (Hg) | ≤ 0.1 ppm |
| Residual Solvents | Complies with USP / EP limits |
| Mesh Size | ≥ 95% pass 80 mesh |
| Total Plate Count | ≤ 1,000 CFU/g |
| Yeast & Mold | ≤ 100 CFU/g |
| E. coli | Negative |
| Salmonella | Negative |
4. Applications
A. Food / Nutraceutical Use
Used in dietary supplements to enhance energy, stamina, and metabolism.
Supports blood circulation and helps maintain normal sexual performance.
Often formulated in capsules, tablets, and energy formulations.
⚠️ Note: Use of Yohimbine in food supplements is regulated and restricted in several countries. Always verify local compliance before use.
B. Industrial / Pharmaceutical Use
Applied as an α2-adrenoceptor antagonist in pharmacological research.
Utilized in pharmaceutical formulations for circulatory and metabolic studies.
Employed as a reference standard and intermediate in chemical synthesis.
5. Storage & Stability
Store in a cool, dry, and well-closed container.
Keep away from moisture, heat, and direct sunlight.
Shelf life: 24 months under proper storage conditions.
6. Packaging
Standard packing: 1 kg / aluminum foil bag, 25 kg / drum.
Custom packaging available upon request.
7. Safety & Handling
Handle with care; avoid inhalation and direct contact with skin or eyes.
Use appropriate personal protective equipment (PPE).
Not intended for direct use in foods in regions where it is regulated.
8. Regulatory Information
Status: Subject to national and regional regulations (e.g., FDA, EFSA).
HS Code: 2939.99
GHS Classification: Irritant (Category 2)
UN Number: Not classified as hazardous for transport under normal conditions.
9. Additional Information
This product is intended for laboratory, research, nutraceutical, and industrial use only.
It is not a drug, and not intended to diagnose, treat, cure, or prevent any disease.
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