| Description |
Xylazine Hydrochloride is α2 class of adrenergic receptor
agonist.Target: Adrenergic ReceptorXylazine is a drug that is used for
sedation, anesthesia, muscle relaxation, and analgesia in animals such
as horses, cattle and other non-human mammals. An analogue of clonidine,
it is an agonist at the α2 class of adrenergic receptor. Xylazine has
recently emerged as a recreational drug, especially in Puerto Rico [1].
Administration of xylazine (0.17 mg/kg of body weight, diluted to a
10-ml volume, using 0.9% NaCl) induced approximately 2.5 hours of local
analgesia without apparent side effects. Higher doses of xylazine caused
mild hind limb ataxia. Administration of lidocaine induced a similar
duration of analgesia, with severe hind limb ataxia (100% incidence). We
concluded that xylazine given by epidural injection results in safe,
effective perineal analgesia in horses [2]. |
| Related Catalog |
Signaling Pathways >>
GPCR/G Protein >>
Adrenergic Receptor
Research Areas >>
Neurological Disease
|
| Solvent |
In Vitro: 10 mM in DMSO
|
| Solubility |
1 mM3.8942 mL19.4712 mL38.9423 mL5 mM0.7788 mL3.8942 mL7.7885 mL10 mM0.3894 mL1.9471 mL3.8942 mL
|
| Storage |
Powder-20°C3 years 4°C2 yearsIn solvent-80°C6 months -20°C1 month
|
| Shipping |
Room temperature in continental US; may vary elsewhere
|
| SMILES |
CC1=C(C(C)=CC=C1)NC2=NCCCS2.Cl
|
| References |
[1]. Reyes,
J.C., et al., The emerging of xylazine as a new drug of abuse and its
health consequences among drug users in Puerto Rico. J Urban Health,
2012. 89(3): p. 519-26. [2]. Hsu,
W.H., Xylazine-induced depression and its antagonism by alpha
adrenergic blocking agents. J Pharmacol Exp Ther, 1981. 218(1): p.
188-92.
|
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