| Name | WS3 |
| Description | WS3, a β cell proliferation inducer, regulates Erb3 binding protein-1 (EBP1) and the IκB kinase pathway. |
| Cell Research | R7T1 cells are growth-arrested by removal of doxycycline for 2 days and plated into 384-well plates at a density of 3,000 cells/well in growth medium. Β cell proliferation is assessed using CellTiter Glo after 4 days. Fold increase in cell number is calculated by normalizing compound-treated wells to the median of DMSO-treated wells. (Only for Reference) |
| In vivo | In the mouse β-cell line R7T1, WS3 induces cell proliferation with an EC50 of 0.074 μM. Additionally, WS3 reversibly induces cell proliferation in primary embryonic and adult retinal pigment epithelial cells. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Saline : < 10 mg/mL (17.56 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 250 mg/mL (438.92 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (17.56 mM), Solution.
Ethanol : 74 mg/mL (129.92 mM), Sonication is recommended.
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| Keywords | β cell | WS-3 | WS3 | WS 3 | RPE | retinal | R7T1 | proliferation | pigment | pancreatic | IκB kinase | IκB | insulin | Inhibitor | inhibit | IKK | IkB/IKK | IkB | ErbB3-Binding Protein-1 (EBP1) | epithelial | diabete |
| Inhibitors Related | Amlexanox | Osimertinib | Lidocaine Hydrochloride hydrate | Lapatinib | Resveratrol | Erlotinib hydrochloride | Erlotinib | Neratinib | Afatinib | Chalcone | Brigatinib | Gefitinib |
| Related Compound Libraries | Bioactive Compounds Library Max | Reprogramming Compound Library | Cytokine Inhibitor Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Bioactive Compound Library | Pyroptosis Compound Library | Stem Cell Differentiation Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Anti-Cancer Compound Library |
United States
