| Name | Tyrphostin AG 538 |
| Description | Tyrphostin AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive. |
| In vitro | Experimentally it is indeed found that AG 538 does not compete with ATP but competes with the IGF-1R substrate. Both AG 538 and I-OMe AG 538 inhibit IGR-1R autophosphorylation in intact cells in a dose-dependent manner. Both compounds inhibit the activation of the downstream targets PKB and Erk2.[1] |
| In vivo | Typical assays used to discover and analyze small molecules that inhibit the hepatitis C virus (HCV) NS3 helicase yield few hits and are often confounded by compound interference. FP-based assay was chosen to screen Sigma's Library of Pharmacologically Active Compounds (LOPAC) for compounds that inhibit NS3-DNA complex formation. Four LOPAC compounds inhibited the FP-based assay: aurintricarboxylic acid (ATA) (IC50=1.4 μM), suramin sodium salt (IC50=3.6 μM), NF 023 hydrate (IC50=6.2 μM) and tyrphostin AG 538 (IC50=3.6 μM).[2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 4.5 mg/mL (15.14 mM), Sonication is recommended.
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| Keywords | Tyrphostin AG-538 | Tyrphostin AG538 | Tyrphostin AG 538 | IGF-1R | IGF1R | AG-538 | AG538 |
| Inhibitors Related | Insulin (human) | MSDC-0602K | Urolithin C | Indirubin Derivative E804 | Ornithine-α-ketoglutarate | (2S,3R,4S)-4-Hydroxyisoleucine | Picropodophyllin | Sorbic acid | Ceritinib | L-Cysteine hydrochloride hydrate | Tranexamic acid | Linsitinib |
| Related Compound Libraries | Anti-Lung Cancer Compound Library | Glycometabolism Compound Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library | Cytokine Inhibitor Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Inhibitor Library | Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
United States
