AG 538 is a potent, competitive inhibitor of IGF-1 receptor kinase, with an IC50 of 400 nM[1].
ChEBI: 3-(3,4-dihydroxyphenyl)-2-[(3,4-dihydroxyphenyl)-oxomethyl]-2-propenenitrile is a member of chalcones.
Cell permeable: yes', 'Primary Target
IGF-1 receptor kinase', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 400 nM against IGF-1 receptor kinase
[1] G Blum, et al. Substrate Competitive Inhibitors of IGF-1 Receptor Kinase. Biochemistry. 2000 Dec 26;39(51):15705-12. DOI:
10.1021/bi001516y
