The active ingredient of treprostinil is a synthetic analog of gonadotropin-releasing hormone (GnRH), also known as tryptophan, dafylline, dabigatran, gonadorelin, an antitumor drug with the same pharmacological effects as goserelin and buserelin, and its structural improvement is to replace the sixth levoglycine in the natural molecular structure with dextro-tryptophan, which results in a more pronounced prokinetic effect and a longer plasma half-life, and higher efficacy. Higher potency. After intramuscular injection, the pituitary gland is initially stimulated to release luteinizing hormone (LH) and follicle stimulating hormone (FSH). When the pituitary gland enters a phase of inappetence after prolonged stimulation, the release of gonadotropins decreases, thus lowering the sex hormones to depot levels. The above effects are reversible. Subcutaneous administration of the drug is rapidly absorbed, Tmax is 15min, 1h to reach the maximum effect, extended-release preparations of intramuscular injection can maintain the efficacy of the treatment for more than 28d. Clinically, it is mainly used for the treatment of endometriosis, hormone-dependent prostate cancer, breast cancer, children's true precocious puberty, but also for assisted reproductive technology. Triptorelin is also called Triptorelin Acetate Injection, which is a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH), but its activity is stronger than that of natural GnRH, and it can regulate luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone (T), and estradiol (E2) levels in the blood of human beings, and it has been used to achieve a variety of purposes.
Brand: Soarwin
EC Number: 637-328-4
CAS No.: 57773-63-4
Molecular Formula: C64H82N18O13
Melting point:>180°C (dec.)
Density: 1.52±0.1 g/cm3(Predicted)
Storage: -20°C
China
