Product Name:Trimethoprim/TMP
CAS Number: 738-70-5
Trimethoprim, with the CAS number 738-70-5, is a highly significant antimicrobial agent widely used in the pharmaceutical industry. It plays a crucial role in the treatment of various bacterial infections and has been a staple in antibiotic therapies.
Trimethoprim exerts its antibacterial effect by selectively inhibiting the enzyme dihydrofolate reductase in bacteria. This enzyme is vital for the synthesis of tetrahydrofolate, which is involved in the production of nucleic acids and proteins. By blocking this enzyme, Trimethoprim disrupts the folate metabolism in bacteria, leading to a deficiency of essential precursors for DNA and RNA synthesis. Since mammalian cells have a different form of dihydrofolate reductase that is much less sensitive to Trimethoprim, the drug exhibits selective toxicity towards bacteria, minimizing harmful effects on the host.
It has a broad antibacterial spectrum, being effective against many Gram-positive and Gram-negative bacteria. It is particularly useful in treating urinary tract infections caused by organisms such as Escherichia coli, Proteus mirabilis, and Klebsiella pneumoniae. Additionally, it is employed in the treatment of respiratory tract infections, including bronchitis and pneumonia, when caused by susceptible bacteria. Skin and soft tissue infections, as well as some gastrointestinal infections, can also be treated with Trimethoprim, either alone or in combination with other antibiotics.
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