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ChemicalBook Product Catalog Tomivosertib

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Tomivosertib NEW

$59.00 1mg

$172.00 5mg

$255.00 10mg

Min. Order
Purity99.67%
Cas No1849590-01-7
Supply Ability10g
Update time2024-11-17

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Tomivosertib
CAS No	1849590-01-7
EC-No
Min. Order
Purity	99.67%
Supply Ability	10g
Release date	2024/11/17

Product Introduction

Bioactivity

名称	Tomivosertib
描述	Tomivosertib (eFT508) is a potent and highly selective MNK1 and MNK2 inhibitor with an IC50 value of 1-2 nM.
细胞实验	TMD8 cells are treated with the indicated concentrations of eFT508 for 24 h. Cell lysates are subjected to m7-GTP Sepharose pull-down and bound proteins are analyzed by immunoblotting with the indicated antibodies. (Only for Reference)
体外活性	Tomivosertib has a half-maximal inhibitory concentration (IC50) of 1-2 nM against both MNK isoforms in enzyme assays and inhibits the kinase through a reversible, ATP-competitive mechanism of action. Treatment of tumor cell lines with Tomivosertib leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC50 = 2-16 nM). In a panel of ~50 hematological cancers, Tomivosertib shows anti-proliferative activity against multiple DLBCL cell lines. Sensitivity to Tomivosertib in TMD8, OCI-Ly3 and HBL1 DLBCL cell lines is associated with dose-dependent decreases in production of pro-inflammatory cytokines including TNFα, IL-6, IL-10 and CXCL10[1].
体内活性	eFT508 is well-tolerated and shows efficacy against MyD88-mutant DLBCL models in vivo. Significant anti-tumor activity of eFT508 is observed in the TMD8 and HBL-1 ABC-DLBCL models(subcutaneous human lymphoma xenograft models), both of which harbor activating MyD88 mutations[1].
存储条件	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	H2O : <1 mg/mL DMSO : 11 mg/mL (32.3 mM) Ethanol : <1 mg/mL
关键字	Inhibitor \| MAP kinase interacting kinase \| MNK \| Mitogen activated protein kinase interacting kinase \| MAPK interacting kinase \| eFT 508 \| eFT-508 \| Tomivosertib \| inhibit
相关产品	LSD1-IN-24 \| PD-1/PD-L1-IN-9 \| Sulfamethoxypyridazine \| PD-1-IN-22 \| BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride \| IMMH 010 maleate \| EB1 \| LSD1-IN-27 \| MK2-IN-3 hydrate \| BMS-1 \| ETC-206 \| PD-L1-IN-3
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