Tolvaptan Sodium Phosphate (CAS 942619-79-6)
🌟 ChemicalBook Product Profile
📌 Product Overview
Tolvaptan Sodium Phosphate (C₂₆H₂₇ClN₂NaO₆P), a phosphate prodrug of Tolvaptan, is a potent vasopressin V2 receptor antagonist with a molecular weight of 552.92 g/mol. This white crystalline powder (≥99.5% purity, HPLC validated) is designed for intravenous diuretic therapy, particularly for patients with fluid retention who cannot tolerate oral medications. It hydrolyzes in vivo to release Tolvaptan, which selectively inhibits water reabsorption in renal tubules, promoting electrolyte-sparing diuresis. Available in 1g/5g/100g sealed aluminum foil packaging with 3-year stability under dry, light-protected conditions.
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✅ Key Advantages
🔹 Ultra-High Purity
≥99.5% purity (HPLC/NMR validated) | Complies with EP/USP/CP standards.
🔹 GMP-Certified Manufacturing
Produced in ISO 9001 and GMP-compliant facilities | REACH and ICH stability compliant.
🔹 Rapid Therapeutic Action
Achieves peak plasma concentration within 2-4 hours post-administration.
🏥 Application Fields
Diuretic Formulations: Core API for IV therapies targeting hyponatremia and heart failure-related edema.
Clinical Research: Key intermediate in developing vasopressin receptor antagonists.
Pharma Bulk Supply: Supports global production of specialty diuretics.
📜 Quality Certifications
Analytical Methods: HPLC, NMR, mass spectrometry, microbial limit testing.
Certifications: GMP, ISO 9001, REACH, and ICH Q1-Q12 guidelines.
📊 Market Trends
The global diuretics market is projected to grow at 5.8% CAGR (2025-2030), driven by rising cardiovascular disorders and demand for targeted renal therapies. Tolvaptan derivatives dominate 35% of the vasopressin antagonist segment, with Asia-Pacific emerging as the primary API production hub.
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