Name | Tin-protoporphyrin IX dichloride |
Description | Tin-protoporphyrin IX dichloride (SnPPIX dichloride) is an HO-1) inhibitor with antiviral activity that inhibits dengue and yellow fever viruses. |
In vitro | In Capan-1, CD18/HPAF, and PDAC cells, Tin protoporphyrin IX dichloride (20 μM, 50 μM; 24 or 72 hours) inhibited proliferation of Capan-1 and CD18/HPAF cells and inhibited growth of PDAC cells at 50 μM[1]. |
In vivo | In male and female athymic nude mice with PDAC cell-derived xenograft tumors, Tin protoporphyrin IX dichloride (5 mg/kg; Intraperitoneal injection; on days 1, 4, 6, 8, 11, 13, 15, 18, and 20) inhibited tumor growth and sensitized tumors to chemotherapy (Gemcitabine)[1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | 0.1M NaOH : 10 mg/mL (13.3 mM), Sonication is recommended. DMSO : 5 mg/mL (6.6 mM), Sonication is recommended.
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Keywords | VirusProtease | Virus Protease | Tin-protoporphyrin IX | Tinprotoporphyrin IX | Tin protoporphyrin IX | Heme oxygenase-1 | Dengue Fever virus | (HO)-1 |
Inhibitors Related | Stavudine | Aceglutamide | Phenytoin sodium | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Valproic Acid | Curcumin | Paeonol | Naringin | Gefitinib |
Related Compound Libraries | Bioactive Compound Library | Autophagy Compound Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library |