| 名称 | Protoporphyrin IX |
| 描述 | Protoporphyrin IX (PPIX) is a tetrapyrrole that is a metabolic precursor of heme, cytochrome c, and chlorophyll. Protoporphyrin IX has been shown to improve liver function, promote cellular tissue respiration, improve protein and glucose metabolism, and resist complement binding. |
| 体外活性 | METHODS: Gastric cancer cells SGC-7901 and MGC-80 were treated with Stigmasterol (2.5-30 µM) for 24-72 h. Cell viability was measured by CCK8 assay.
RESULTS: Stigmasterol significantly inhibited the viability of SGC-7901 and MGC-803 cells in a time- and dose-dependent manner. [1]
METHODS: Ovarian cancer cells ES2 and OV90 were treated with Stigmasterol (5-20 µg/mL) for 24 h, and the expression levels of target proteins were detected by Western Blot.
RESULTS: Stigmasterol stimulated caspase 3 and caspase 9 cleavage in a dose-dependent manner in each cell type. cytochrome c, BAK and BAX were activated by Stigmasterol in both cell types. alpha-tubulin levels were unchanged after Stigmasterol treatment. The level of alpha-tubulin did not change after Stigmasterol treatment. [2] |
| 体内活性 | METHODS: To investigate the role in allergic skin reactions, Stigmasterol (10-100 mg/kg) was administered intraperitoneally to ICR mice with induced irritant dermatitis.
RESULTS: Stigmasterol significantly inhibited IgE-mediated active cutaneous allergic reactions (ACA), reducing the area of reaction and the concentration of exuded Evans blue dye. Stigmasterol significantly inhibited C48/80-induced scratching behavior compared to control. Skin histopathology at the injection site confirmed that Stigmasterol reduced mast cell transport and degranulation associated with C48/80-induced itching. [3] |
| 存储条件 | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 5.63 mg/mL (10 mM)
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| 关键字 | inhibit | Endogenous Metabolite | Protoporphyrin IX | Inhibitor |
| 相关产品 | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Vanillin | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid | Oleic acid |
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United States
