Thiamine nitrate NEW

Thiamine mononitrate is a stable nitrate salt form of thiamine (vitamin B1). It occurs as a white crystalline powder and is prepared from thiamine hydrochloride. It is used as a food or nutritional supplement and is the preferred form of the vitamin for food fortification. Thiamin mononitrate is used in the pharmaceutical industry to treat beriberi and general malnutrition or malabsorption. Thiamine can be found naturally in foods like grains, yeast, molasses, pork and animal organ meats. Dairy, eggs and legumes have smaller amounts.
Though thiamine is found naturally in foods, thiamine mononitrate is not. Thiamine mononitrate is synthesized by removing a chloride ion from thiamin hydrochloride and mixing the final product with nitric acid. Thiamine hydrochloride is hygroscopic (water-absorbing) whereas the mononitrate has almost no hygroscopic properties. For this reason, the mononitrate is the more stable form of the vitamin in fortified flours and cereals.
Thiamine mononitrate is also specifically known as mononitrate de thiamine, nitrate de thiamine, and thiamine nitrate. In addition, as a vitamer of thiamine, it is also known by all the generic names of thiamine, such as thiamine, antiberiberi factor, antiberiberi vitamin, antineuritic factor, antineuritic vitamin, facteur anti-béribéri, facteur antineuritique, tiamina, vitamin B1, vitamin B-1, vitamina B1, vitamine anti-béribéri, vitamine antineuritique, vitamine B1.

Appearance and properties: white crystal powder

Melting point: 196-200°C

Stability: Stable. Incompatible with strong oxidizing agents.

Production method

Vitamin B1 is naturally found in rice bran, bran, lean meat, peanuts and other foods, and the pure product is usually prepared by chemical synthesis. Excessive acetamidine hydrochloride is condensed with α-dimethoxy-β-methoxy-propanitrile in alkaline (methanol and sodium methanol) media to 3, 6-dimethyl-1, 2-dihydro-2,4,5, 7-tetrazonium naphthalene, and then hydrolyzed at 98-100℃, and then opened under alkaline conditions to form 2-methyl-4-amino-5-aminomethacil; Then it reacts with carbon disulfide and ammonia water, then condenses with acetic acid-γ-chloro-γ-levulyl ester, then hydrolyzes in hydrochloric acid at 75-78℃ and synthesizes cyclothiamine hydrochloride, and finally neutralized with ammonia water, oxidized with hydrogen peroxide and acidified with hydrochloric acid to obtain thiamine hydrochloride.

Use

Vitamin B1 is an important water-soluble vitamin to maintain the normal function of the nervous system and digestive system. It participates in the formation of coenzymes in the body and maintains sugar metabolism.

Thiamine mononitrate (CAS NO.532-43-4) is applicable to vitamin B1 deficiency, maintain normal metabolism and nerve conduction function. It is also used in adjuvant therapy for indigestion, neuropathy, etc.

COMPANY PROFILE

Hebei yanxi chemical co.,Itd is a professional research and development of the production of lead acetate,2-phenylethylamide enterprises.The key members of the company are established by local well-known entrepreneurs and professional engineers under the call and support of the party's"low-carbon environmental protectionsafety and stability"under the innovation in traditional production equipment and technology,the use of"high temperature cooling"and "plastic basin crystallization"technology,on the basis of reducing the cost of products to make the quality of products to the same industryWith the efforts of all the staff of the companywe have established many cooperative companies in Shan Dong,He Nan,Guang Dong and other places in recent decades. Under the close supervision of the quality inspection department of the company,we carry out production and sales in the way of "labeling",providing the most convenient and fastest service for users all over the countryCompanies in the"advance with The Timesand the city every day with the advancement of"under the guidance of the core ideasadhering to the"relying on scientific and technological innovationthe development of circular economy" of the enterprise purpose,established in the marketenhance strength,go the way of science and environmental sustainable developmentrelying on the national technology research and development center, increasing spending on research and development based on the domestic market, expand the international marketmanufacturing high quality productssincere service society,toward a modern, ecology, science and technologychemical enterprises of the world.