| Name | Tetracycline hydrochloride |
| Description | Tetracycline hydrochloride (NCI-c55561) is the hydrochloride salt of the tetracycline, a broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis and bacterial cell growth. Because naturally, fluorescing tetracycline binds to a newly formed bone at the bone/osteoid interface, tetracycline-labeling of bone and fluorescence microscopy may be used to perform bone histomorphometry. |
| In vitro | Tetracyclines are versatile broad-spectrum antibiotics effective against a vast array of organisms, including gram-positive and gram-negative bacteria, as well as atypical pathogens like chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites. Their mechanism of action involves blocking bacterial protein synthesis by hindering the binding of aminoacyl-tRNA to the bacterial ribosome. Specifically, in gram-negative enteric bacteria, tetracyclines enter through OmpF and OmpC porin channels as positively charged coordination complexes, likely involving magnesium ([1]). |
| In vivo | Tetracyclines are utilized for managing infections in various livestock, including poultry, cattle, sheep, and swine, and in aquaculture species such as salmon, catfish, and lobsters[2]. In specific scenarios, such as treating large populations of commercially farmed poultry, these antibiotics may be administered directly through feed, water, or aerosols. Additionally, tetracyclines may serve to promote or enhance growth. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (93.57 mM), Sonication is recommended.
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
H2O : 88 mg/mL (182.99 mM), Sonication is recommended.
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| Keywords | Tetracycline hydrochloride | Tetracycline Hydrochloride | Tetracycline | Inhibitor | inhibit | Bacterial | Antibiotic | 30S ribosome |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Methyl anthranilate | Doxycycline (hyclate) | Kanamycin sulfate | Urethane | Sulfamethoxazole sodium | Doxycycline | EDTA copper(II) disodium salt | Isoeugenol | Dimethyl sulfoxide |
| Related Compound Libraries | Bioactive Compound Library | Toxic Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Natural Product Library | Inhibitor Library | Microbial Natural Product Library | NO PAINS Compound Library | Natural Product Library for HTS | FDA-Approved Drug Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max |
United States