| Name | Synephrine |
| Description | Synephrine (Oxedrine) is sympathetic alpha-adrenergic agonist used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma. |
| In vitro | Synephrine is a compound commonly used for weight loss. Synephrine has gained significant popularity as an alternative to ephedrine. Products containing bitter orange or synephrine are suspected of causing adverse cardiovascular reactions. [1] [2] Synephrine can stimulate glucose consumption (Glut4-dependent glucose uptake) by stimulating AMPK activity, regardless of insulin-stimulated PI3 kinase-Akt activity in L6 skeletal muscle cells. [3] |
| In vivo | LD50: Mice >1000 mg/kg (s.c.) [4] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 2 mg/mL (11.96 mM), Heating is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (19.74 mM), Sonication is recommended. DMSO : 85 mg/mL (508.34 mM), Sonication is recommended.
|
| Keywords | β-adrenergic | α-adrenergic | weight | Synephrine | sympathomimetic | loss | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite | Beta Receptor | alkaloid | AdrenergicReceptor | Adrenergic Receptor |
| Inhibitors Related | Sucrose | Aceglutamide | Cysteamine hydrochloride | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Miao medicine Compound Library | Anti-Cancer Approved Drug Library | Natural Product Library for HTS | Bioactive Compounds Library Max | GPCR Compound Library | Ancient Chinese Classical Formulas Compound Library |