| Name | Synephrine |
| Description | Synephrine (Oxedrine) is sympathetic alpha-adrenergic agonist used as a vasoconstrictor in circulatory failure, asthma, nasal congestion, and glaucoma. |
| In vitro | Synephrine is a compound commonly used for weight loss. Synephrine has gained significant popularity as an alternative to ephedrine. Products containing bitter orange or synephrine are suspected of causing adverse cardiovascular reactions. [1] [2] Synephrine can stimulate glucose consumption (Glut4-dependent glucose uptake) by stimulating AMPK activity, regardless of insulin-stimulated PI3 kinase-Akt activity in L6 skeletal muscle cells. [3] |
| In vivo | LD50: Mice >1000 mg/kg (s.c.) [4] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 2 mg/mL (11.96 mM), Heating is recommended.
10% DMSO+90% Saline : 8.33 mg/mL (49.82 mM), Solution.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (19.74 mM), Sonication is recommended.
DMSO : 83.33 mg/mL (498.36 mM), Sonication is recommended.
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| Keywords | β-adrenergic | α-adrenergic | weight | Synephrine | sympathomimetic | loss | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite | Beta Receptor | alkaloid | AdrenergicReceptor | Adrenergic Receptor |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium | DL-Lysine |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Alkaloid Natural Product Library | Membrane Protein-targeted Compound Library | Natural Product Library | Drug Repurposing Compound Library | Natural Product Library for HTS | Anti-Cancer Approved Drug Library | GPCR Compound Library | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Drug Library | Food as Medicine Compound Library |
United States
