Sucralose is the highest level product of high sweetness sweetener development and research in the world, and has excellent performance. Sucralose is a white powder product, highly soluble in water (solubility 28.2g, 20℃), sweetness is 600 times that of sucrose, and pure sweetness, sweetness characteristic curve almost overlaps with sucrose. Sucralose is a non-nutritive strong sweetener that is almost not absorbed in the human body and has a zero calorie value. Sucralose is stable and its crystalline products are also stable when stored for 4 years under dry conditions at 20 ° C. In aqueous solution, in the soft drink pH range (pH3-5) and at normal temperatures, sucralose is the most stable of all powerful sweeteners and can be stored for more than one year without any change. Non-nutritional sweetener, widely used in beverage, food, medicine, cosmetics and other industries, because sucralose is a new type of non-nutritional sweetener, is an ideal food additive for patients with obesity, cardiovascular disease and diabetes, therefore, its application in health food and medicine continues to expand. In recent years, it has been used as a tracer molecule for the determination of colon permeability in medical studies, and the method used is mostly meteorological chromatography. The sensitivity and specificity need to be further studied. The product is the most ideal strong sweetener available today for children, adolescents, young adults, middle-aged, elderly and patients with various diseases, without any nutritional concerns.