名称 | Stavudine |
描述 | Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV. |
体外活性 | In lean mice, Stavudine (500 mg/kg/day) reduces mitochondrial DNA in the liver and muscle, inducing ketoacidosis during fasting periods. In obese mice, Stavudine (500 mg/kg/day) depletes mtDNA in White Adipose Tissue (WAT). |
体内活性 | Stavudine reduces lipid content and influences the expression of lipid metabolism markers, such as C/EBPα, peroxisome proliferator-activated receptor γ, adipocyte lipid-binding protein 2, fatty acid synthase, and acetyl-CoA carboxylase. In 3T3-F442A cells, Stavudine induces apoptosis and reduces both lipid content and viability in 3T3-L1 adipocytes. Furthermore, in peripheral blood mononuclear cells (PBMC), Stavudine inhibits the production of p24 antigen by HIV-1, with an effective dose range of 0.04 μM to 0.2 μM (ED50 = 0.04 μM-0.2 μM). |
存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 50 mg/mL (223.01 mM) H2O : 22.4 mg/mL (100 mM)
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关键字 | BMY27857 | nucleoside | inflammasome | Autophagy | NSC-163661 | mtDNA | Apoptosis | inhibit | HIV | NOD-like Receptor (NLR) | antiretroviral | analogue | Stavudine | Inhibitor | Reverse Transcriptase | Human immunodeficiency virus | Amyloid-β | NSC163661 | BMY 27857 | Nucleoside Antimetabolite/Analog |
相关产品 | Emtricitabine | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Lamivudine | Tributyrin | Paeonol | Naringin |
相关库 | 经典已知活性库 | EMA 上市药物库 | 抗癌临床化合物库 | 药物功能重定位化合物库 | 抗病毒库 | 抑制剂库 | 抗癌上市药物库 | FDA 上市药物库 | 抗衰老化合物库 | 抗癌药物库 |