| Name | Silibinin |
| Description | Silibinin (Silybin) is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin and others. Silibinin itself is a mixture of two diastereomers, silybin A and silybin B, in approximately equimolar ratio. Both in vitro and animal research suggest that silibinin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins. Silibinin has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells. |
| In vivo | Research indicates that silibinin protects liver cells from toxin-induced damage, serving a hepatoprotective function. In vitro, studies demonstrate that silibinin exhibits anticancer effects against a variety of human cancer cells, including prostate cancer cells, estrogen-dependent/independent breast cancer cells, colorectal cancer cells, cervical cancer cells, and both small and non-small cell lung cancer cells. Silibinin is a mixture of the diastereoisomers silibinin A and silibinin B, approximately in a 1:1 ratio. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (6.84 mM), Sonication is recommeded.
DMSO : 260 mg/mL (538.93 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
|
| Keywords | Silibinin | ReactiveOxygenSpecies | Reactive Oxygen Species | Inhibitor | inhibit | Autophagy |
| Inhibitors Related | Ethoxyquin | Kaolin | Stavudine | Aceglutamide | Allopurinol | Cysteamine hydrochloride | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Paeonol | Naringin | Alginic acid |
| Related Compound Libraries | Polyphenolic Natural Product Library | Flavonoid Natural Product Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library for HTS | Bitter Compound library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
United States
