| CAS: | 22888-70-6 |
| MF: | C25H22O10 |
| MW: | 482.44 |
| EINECS: | 245-302-5 |
| Product Categories: | Aromatics;Chiral Reagents;Angiogenesis InhibitorsCancer Research;Anti-proliferative AgentsNutrition Research;Angiogenesis;Biochemicals Found in Plants;Flavanones;Natural Plant Extract;Bioflavonoids;Cancer Research;Chemopreventive Agents;chemical reagent;Plant extract;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical raw material;Plant extracts;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
| Mol File: | 22888-70-6.mol |
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| Silibinin Chemical Properties |
| Melting point | 164-174°C |
| alpha | D20 +11° (c = 0.25 in acetone + alcohol) |
| Boiling point | 793.0±60.0 °C(Predicted) |
| density | 1.527±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Acetone (Sparingly), DMSO, Methano (Sparingly) |
| form | Solid |
| pka | pKa 6.42±0.04 (Uncertain) |
| color | Pale Yellow |
| Water Solubility | 54mg/L(24.99 ºC) |
| Merck | 13,8607 |
| Stability: | Stable. Incompatible with strong oxidizing agents, strong bases. |
| LogP | 4.232 (est) |
| CAS DataBase Reference | 22888-70-6(CAS DataBase Reference) |
| Silibinin Usage And Synthesis |
| Chemical Properties | solid |
| Originator | Legalon,Madaus,W. Germany,1969 |
| Uses | Silibinin has been used:
to study its effect on gene expression levels of various proteins involved in chromatin regulations of prostate cancer, by real time polymerase chain reaction (RT-PCR) to study its effect on cell proliferation in platelet-derived growth factor (PDGF)-treated human tenon′s fibroblasts (HTFs) by investigating the expression of proliferating cell nuclear antigen (PCNA) and by water-soluble tetrazolium salt (WST-1) assay to examine its effect on gene expression levels of stromelysine 1 (STM1), acetyl hexoseamines and collagen production during skin wound healing to study its inhibitory effect on Escherichia coli ATP synthase
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| Uses | Labelled Silybin (S465850). Hepatoprotectant. |
| Definition | ChEBI: A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities. |
| Manufacturing Process | Silymarin comprising polyhydroxyphenyl chromanones is recovered from the dried fruit of Silybum marianum Gaertn. by separating the fatty oils therefrom, extracting the remaining solid residue with ethyl acetate, evaporating the ethyl acetate and dissolving the dry residue in a solvent mixture comprising methanol, water and petroleum ether to form a two-phase system wherein the chromanones are contained in the lower phase, recovering the polyhydroxyphenyl chromanones from the lower phase after subjecting same to multiple counter-current contact with petroleum ether. |
| Therapeutic Function | Hepatoprotectant |
| General Description | Silibinin, a principal component of silymarin, is a flavonolignan and an orally active flavonoid. It is isolated from the seeds of milk thistle (Sylibum marianum L). |
| Biochem/physiol Actions | Silibinin functions as a hepatoprotectant in patients with acute and chronic liver injury. This flavonoid fights against various cancer cells including, prostate, skin, breast, colon, lung, bladder and hepatocellular carcinoma (HCC). Silibinin exhibits its efficacy as an anti-cancer agent by blocking the secretion of proangiogenic factors from tumor cells, and by hindering growth and inducing apoptotic death of endothelial cells. In addition, it also interrupts capillary tube formation on Matrigel. Silibinin might be a good candidate for chemoprevention of prostate cancer (PC). It might be used as a potential therapeutic regimen for the treatment of endometriosis in vitro and in vivo. |
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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