| Name | Sertindole |
| Description | Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C, with Kds of 2.7, 20, 0.14, and 6 nM, respectively. |
| Animal Research | Rats were treated acutely with vehicle or drugs, and extracellular levels of neurotransmitters were assessed by microdialysis in freely moving animals[1]. |
| In vivo | In vivo, sertindole (10 mg/kg) increases extracellular dopamine, acetylcholine (ACh), and glutamate levels in the medial prefrontal cortex in conscious rats[1].Sertindole (2.5 mg/kg) reverses ketamine-induced impairments in the extradimensional shift stage of the attentional set-shifting task (ASST) in rats[2].It reverses phencyclidine (PCP)-induced selective reversal learning deficits in rats and subchronic PCP-induced deficits in the novel object recognition task in mice[3]. |
| Storage | keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : < 1 mg/mL (insoluble), Sonication is recommended.
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| Keywords | U87-MG | U251 | U118-MG | T47D | SW620 | SW480 | SUM159 | SGC-7901 | Sertindole | Serotonin Receptor | NCI-H661 | NCI-H460 | NCI-H446 | MKN45 | MCF-7 | MCF-10A | K562 | Jurkat | Inhibitor | inhibit | HT-29 | HepG2 | HCT-15 | DopamineReceptor | Dopamine Receptor | Dopamine | D2 | COLO205 | CCRF-CEM | BGC-823 | Beta Receptor | Bel-7402 | Autophagy | antipsychotic activity | anti-proliferative activity | AGS | AdrenergicReceptor | Adrenergic Receptor | A549 | A172 | 801-D | 5-hydroxytryptamine Receptor | 5HTReceptor | 5-HT Receptor | 5HT Receptor | 5-HT |
| Inhibitors Related | Stavudine | Cysteamine hydrochloride | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Valproic Acid | Curcumin | Paeonol | Naringin | Alginic acid | Gefitinib |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | GPCR Compound Library | Anti-Cancer Drug Library |