| Name | Sertindole |
| Description | Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C, with Kds of 2.7, 20, 0.14, and 6 nM, respectively. |
| Animal Research | Rats were treated acutely with vehicle or drugs, and extracellular levels of neurotransmitters were assessed by microdialysis in freely moving animals[1]. |
| In vivo | In vivo, sertindole (10 mg/kg) increases extracellular dopamine, acetylcholine (ACh), and glutamate levels in the medial prefrontal cortex in conscious rats[1].Sertindole (2.5 mg/kg) reverses ketamine-induced impairments in the extradimensional shift stage of the attentional set-shifting task (ASST) in rats[2].It reverses phencyclidine (PCP)-induced selective reversal learning deficits in rats and subchronic PCP-induced deficits in the novel object recognition task in mice[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (113.39 mM)
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| Keywords | Jurkat | A172 | MCF-7 | anti-proliferative activity | U118-MG | MKN45 | 5-HT Receptor | Bel-7402 | Autophagy | SW480 | COLO205 | SUM159 | NCI-H661 | SW620 | Beta Receptor | CCRF-CEM | HCT-15 | SGC-7901 | 801-D | Serotonin Receptor | 5-hydroxytryptamine Receptor | NCI-H460 | NCI-H446 | U87-MG | BGC-823 | HT-29 | K562 | inhibit | U251 | MCF-10A | T47D | Adrenergic Receptor | AGS | Dopamine Receptor | antipsychotic activity | A549 | HepG2 | Sertindole | Inhibitor |
| Inhibitors Related | Stavudine | Xylitol | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Curcumin | Oxyresveratrol | Paeonol | Naringin | Salicylic acid | Gefitinib |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | GPCR Compound Library |
United States
