Chemical Properties
Off-White to Pale Yellow Solid
Usage
Antipsychotic used in the treatment of schizophrenia.
Usage
antipsychotic;Dopamine D2/Serotonin 5-HT2 receptor antagonist
Description
Serdolect was launched in the UK for acute and chronic schizophrenia and
schizoaffective psychoses. It is synthetically available in three steps from 5chloro-l-
(4-fluorophenyl)-l H-indole. Sertindole is selective for the limbic areas of the brain
and has a high affinity for the serotinin 5-HT2 receptor where it behaves as an
antagonist. It has weak affinity for the α1-adrenergic receptor and no affinity for
dopamine D2 receptors. It is as effective as haloperidol but without the
extrapyramidal symptoms. This may be a consequence of the fact that it expresses
the c-fos protein in a manner different for haloperidol but similar to clozapine. It is
non-sedating, long lasting (several days after a single dose) and has an atypical
mode of action.
Originator
Lundbeck (Denmark)
Uses
Antipsychotic used in the treatment of schizophrenia.
Uses
antipsychotic;Dopamine D2/Serotonin 5-HT2 receptor antagonist
Definition
ChEBI: A phenylindole that is 1H-indole which is substituted on the nitrogen by a p-chlorophenyl group, at position 5 by chlorine, and at position 3 by a piperidin-4-yl group, which is itself substituted on the nitrogen by a 2-(2-o
oimidazolidin-1-yl)ethyl group.
Brand name
SerLect (Abbott).
Side effects
Sertindole is an indole-containing compound that behaves as a high-affinity serotonin 5-HT2 receptor antagonist,
with weak affinity for adrenergic α1 receptors and almost no affinity for dopaminergic D2 receptors. It is about as
effective as haloperidol in the treatment of acute and chronic schizophrenia, but with much lower incidence of
extrapyramidal side effects. Sertindole is relatively nonsedating, and its effects are long lasting (several days).
