What is Sermorelin?
Sermorelin is a synthetic (man-made) version of a naturally occurring substance that causes release of growth hormone from the pituitary gland. Growth hormone is naturally produced by the pituitary gland and is necessary for growth in children. In children who fail to grow normally because their bodies are not producing enough growth hormone, this medicine may be used to increase the amount of growth hormone produced by the pituitary gland.
1.What peptide purification methods do you use?
Theoretical net peptide content (calculated assuming that counterions are the only non-peptide components present in your In most cases, we use preparative RP-HPLC for peptide purification. Occasionally, ion exchange chromatography (IEX) may be utilized as well. IEX is particularly useful in the case of pegylated peptides for removal of the free, unreacted PEG. Additionally, size exclusion (SEC) may be used to remove high-molecular-weight impurities and polymers such as with multi-disulfide peptides.
2.Why do some of your COA's show over 100% purity?
The reference standard that 3rd party labs use to measure products against is also minimum 98% purity. In the case that our products come purer than the reference standard, a result as high as 101.9% can be seen on the test indicating a 98% reference standard and 99.9% pure sample.
3.How are you able to offer such competitive prices?
Our prices are based on operational costs plus a small margin that allows us to invest in the development of new products. Our leverage is volume and industry experience. We purchase materials in bulk to take advantage of economies of scale in manufacturing and quality control.
4.What is the maximum peptide length you can synthesize?
We can synthesize peptides of lengths up to ~80 residues. Peptide lengths of 10 to 70 residues can usually be made by direct solid phase peptide synthesis (SPPS) chemical synthesis. Depending upon the scale and future requirements, combined strategies of using solution fragment condensation or even hybrid methods involving solid-phase couplings of protected peptide fragments may be developed specifically for each product. We also can utilize native chemical ligation (NCL) to make longer peptides and potentially mini-proteins using fully deprotected peptide fragments with an N-terminal Cys residue and another fragment containing a C-terminal thioester. While we have successfully manufactured peptides >80 residues, peptides greater than 80 amino acids are often more viably manufactured via a recombinant synthesis. On the other hand, peptides with 2-10 amino acids are often manufactured by solution or liquid phase peptide synthesis (LPPS).
5.What methods do you use to synthesize peptides?
We typically use Fmoc-tBu solid-phase peptide synthesis (SPPS), but we are also very skilled in the art of classical (solution phase or liquid phase peptide synthesis (LPPS)), and hybrid synthesis methods. Hybrid synthesis technology utilizes fully protected peptide fragments that are coupled onto resin-bound peptide fragments. For very long peptides, we may even consider native chemical ligation (NCL) approaches.
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