Overview Sermorelin is a synthetic growth hormone releasing hormone with 29 amino acid polypeptide, which is the amino terminal fragment of endogenous growth hormone releasing hormone (GHRH) and has significant effects on regulating growth. It is suggested that neuropeptides/neurotransmitters, hormones and cytokines are the "common language" of mutual regulation between the nervous system, endocrine system and immune system. In addition to its very fine regulatory mechanism, the immune system is also regulated by the neuro-endocrine-immune network. Sermorelin is a synthetic polypeptide distinct from growth hormone-releasing hormone (GHRH) that acts by prompting the pituitary gland to release growth hormone. The results showed that sermorelin could antagonize the immunosuppressive effect of cyclophosphamide in mice. In the immune system of the body, macrophages play an important role in specific and non-specific cellular immune function and immune regulation. Sermorelin can significantly increase the weight of thymus and spleen of immune organs in immunocompromised mice, and improve the phagocytic function of mononuclear phagocytes, suggesting that it can enhance the non-specific immune function of mice. Cyclophosphamide can inhibit the proliferation of T lymphocytes, and sermorelin can significantly counter the toxic effect of CY on lymphocytes and restore the proliferation of T lymphocytes. Dinitrochlorobenzene (DChemicalbookNCB) is a kind of antigen, once it infiltrates into the skin, it binds to the skin protein to form a complete antigen, stimulates the proliferation of T lymphocytes into sensitized lymphocytes, and produces delayed hypersensitivity reaction when exposed to DNCB again. The cellular immune function of the body can be judged by the degree of ear swelling, and sermorelin can increase ear swelling in immunosuppressed mice Swelling. At the same time, it also increases the content of IL-2, which is mainly produced by T lymphocytes, so it can indirectly reflect the function of cellular immunity. These results suggest that sermorelin can improve the cellular immune function of immunosuppressed mice, indicating that it has certain immunomodulatory effects and can restore the suppressed immune function to near normal level, especially at high doses, but there is no significant difference between high and low doses, indicating that there is no dose dependence. Its mechanism may be through promoting the release of growth hormone (GH) and play a role,GH is a precursor pituitary hormone, has a wide impact on the immune system, almost all immune cells have the role of promoting differentiation and enhancing function,GH regulation of the immune system may be achieved by regulating the growth of lymphoid tissue, so sermorelin enhancement of the immune system It may also be done with GH; Another possibility is that sermorelin itself has the effect of enhancing immune function, the specific mechanism needs to be further studied.
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