名称 | SEP-363856 hydrochloride |
描述 | SEP-363856 hydrochloride (SEP-856 hydrochloride) is an orally active, CNS-active psychotropic agent with a unique non-D2/5-HT2A mechanism of action, demonstrating antipsychotic-like effects and potential for schizophrenia treatment. |
体外活性 | SEP-856 (10μM) specifically inhibits α2A, α2B, D2, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C and 5-HT7> 50% receptor. |
体内活性 | SEP-856 (0.3, 1, and 10 mg/kg, i.p.) is CNS active and exhibits a behavioral signature similar to known antipsychotic drugs. PCP-induced hyperactivity is significantly reduced by SEP-856 (0.3, 1, and 10 mg/kg, orally once). Oral SEP-856 administration (1, 3, and 10 mg/kg) produces a dose-dependent decrease in REM sleep, increase in latency to REM sleep, and increase in cumulative wake (W) time. |
存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 55 mg/mL (250.31 mM), Sonication is recommended.
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关键字 | Inhibitor | SEP 856 | SEP856 | SEP-363856 Hydrochloride | SEP363856 | SEP-856 Hydrochloride | SEP 363856 hydrochloride | 5-hydroxytryptamine Receptor | inhibit | Serotonin Receptor | SEP363856 Hydrochloride | SEP363856 hydrochloride | SEP-363856 | SEP 363856 | SEP-856 | SEP856 Hydrochloride | SEP 363856 Hydrochloride | SEP 856 Hydrochloride | 5-HT Receptor |
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