Name | SC-514 |
Description | SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression. |
In vitro | In nude mice implanted with A375 or G361 tumors, daily treatment was administered with SC-514 (25 mg/kg). |
In vivo | In rheumatoid arthritis synovial fibroblasts (RASFs), SC-514 (100 μM) inhibits the phosphorylation and degradation of IκBα, while also preventing the translocation of p65 into the nucleus. In the presence of IL-1β-induced inflammation, SC-514 effectively suppresses the expression of NF-κB-dependent genes: IL-6 (IC50=20 μM), IL-8 (IC50=20 μM), and COX-2 (IC50=8 μM). |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 40 mg/mL (178.33 mM), Sonication is recommended. Ethanol : 2.2 mg/mL (10 mM)
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Keywords | IKK | I kappa B kinase | GK01140 | SC514 | SC-514 | GK-01140 | SC 514 | IκB kinase | Inhibitor | inhibit |
Inhibitors Related | Ribociclib | Amlexanox | AEBSF hydrochloride | Resveratrol | Bakuchiol | SB 202190 | (-)-Bornyl acetate | CASIN | Palbociclib | Sodium Oxamate | Abemaciclib | Benzamidine hydrochloride |
Related Compound Libraries | Highly Selective Inhibitor Library | Apoptosis Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Cancer Cell Differentiation Compound Library | Kinase Inhibitor Library | Inhibitor Library | NO PAINS Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |