| Name | Salvianolic acid A |
| Description | Salvianolic acid A (Dan Phenolic Acid A) is a natural product and an inhibitor of matrix metalloproteinase 9 (MMP-9). Salvianolic acid A has antioxidant and anti-inflammatory activity and protects the blood-brain barrier. |
| In vitro | METHODS: Five tumor cell lines, SKOV3, HeLa, NCI-H1975, DU145 and A549, were treated with Salvianolic acid A (1.56-100 µM) for 72 h. Cell viability was measured by CellTiter-Glo kit.
RESULTS: The growth of SKOV3, HeLa, NCI-H1975, DU145 and A549 cells was inhibited with increasing concentrations of Salvianolic acid A, with IC50s of 30.84 µM, 15.85 µM, 10.19 µM, 9.512 µM and 6.461 µM, respectively. [1]
METHODS: Rat cardiomyocytes H9C2 were treated with Salvianolic acid A (50 µM) and Doxorubicin (4 µM) for 12 h. Apoptosis was detected by TUNEL assay.
RESULTS: The number of apoptotic cells increased significantly after Dox stimulation. H9C2 cells co-treated with Dox and Salvianolic acid A exhibited significantly lower apoptosis rates compared to cells exposed to Dox. Salvianolic acid A inhibited Dox-induced apoptosis in H9C2 cells. [2] |
| In vivo | METHODS: In order to investigate the effects on amnesia in mice, Salvianolic acid A (10-40 mg/kg) was administered orally once daily for five days to a C57BL/6 mouse model of amnesia induced by diazepam.
RESULTS: Salvianolic acid A exerts an antiamnesic effect on diazepam-induced paracrine amnesia in mice by enhancing the antioxidant capacity of the hippocampus. [3] |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (91.01 mM)
10% DMSO+90% Saline : 13 mg/mL (26.29 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
Ethanol : 10 mg/mL
|
| Keywords | Matrix metalloproteinases | inhibit | MMP | Salvianolic acid A | Inhibitor |
| Inhibitors Related | Stigmasterol | Ethyl gallate | Doxycycline (hyclate) | Astragaloside IV | Doxycycline | Edaravone | Glucosamine | Bovine Type II Collagen | Triolein | Arctigenin | Fenofibric acid | Glucosamine sulfate |
| Related Compound Libraries | 抗癌天然产物库 | 经典已知活性库 | 中药单体化合物库 | 抗癌临床化合物库 | 抑制剂库 | 高通量筛选天然产物库 | 抗感染天然产物库 | 已知活性化合物库 | 抗病毒中药单体化合物库 | 药食同源库 |
United States
