Product Name: (S)-Timolol maleate
Synonyms: 2-Propanol, 1-(1,1-dimethylethyl)amino-3-4-(4-morpholinyl)-1,2,5-thiadiazol-3-yloxy-, (2S)-, (2Z)-2-butenedioate (1:1) (salt);TIMOLOL HYDROGENMALEATE;TIMOLOL MALEATE;TIMOLOL MALEATE SALT;(S)-TIMOLOL MALEATE;(s)-3-[3-(tert-butylamino)-2-hydroxypropoxy]-4-morpholino-1,2,5-thiadiazole monomaleate;S-(-)-1-[T-BUTYLAMINO]-3-[(4-MORPHOLINO-1,2,5-THIADIAZOL-3-YL)OXY]-2-PROPANOL MALEATE SALT;S[-]-1-[T-BUTYLAMINO]-3-(4-MORPHOLINO-1,2,5-THIADIAZOL-3-YL)OXY]-2-PROPANOL MALEATE SALT
CAS: 26921-17-5
MF: C17H28N4O7S
MW: 432.49
EINECS: 248-111-5
Product Categories: BLOCADREN;Active Pharmaceutical Ingredients;Adrenoceptor;26921-17-5
Timolol is a non-selective β-adrenergic receptor antagonist with log Kd values of -8.27, -9.86, and -6.8 for binding to human β1-, β2-, and β3-adrenoceptors, respectively. It has been reported that only the (S) enantiomer contributes to the β-blocking effects of racemic timolol, but the weakly active (R) isomer maintains a beneficial effect on intraocular pressure without the undesirable side-effect of bronchial constriction caused by non-selective action of (S)-timolol on β1 and β2 receptors. Timolol has been use alone and in fixed combinations with either prostaglandin analogs or carbonic anhydrase inhibitors to reduce intraocular pressure in research models of ocular hypertension and glaucoma.
China
