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ChemicalBook Product Catalog Organic Chemistry Carboxylic acids and derivatives (S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID

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(S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID

$ 1.00 /1KG

Min. Order1KG
Purity98%
Cas No5708-19-0
Supply Ability1000KGS
Update time2023-04-25

Zhengzhou Anbu Chem Co.,Ltd

2YR

China

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Chemical Properties

Product Name	(S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID
CAS No	5708-19-0
EC-No
Min. Order	1KG
Purity	98%
Supply Ability	1000KGS
Release date	2023/04/25

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(S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID Basic information

Product Name:	(S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID
Synonyms:	(1S)-cyclohex-3-ene-1-carboxylic acid;(S)-Cyclohex-3-enecarboxylic acid;(S)-3-Cyclohexene-1-carboxylic Acid;(S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID;(S)-(?)-1,2,3,6-Tetrahydrobenzoic acid;(1S)-CYCLOHEX-3-ENE-1-CARBOXYLIC ACID(1S)-CYCLOHEX-3-ENE-1-CARBOXYLIC ACID;(1S)-3-Cyclohexene-1-carboxylic acid;(S)-(-)-3-Cyclohexene-1-carboxylic Acid
CAS:	5708-19-0
MF:	C7H10O2
MW:	126.15
EINECS:	634-675-3
Product Categories:	Edoxaban
Mol File:	5708-19-0.mol


(S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID Chemical Properties
Melting point	19°C(lit.)
Boiling point	118°C/6mmHg(lit.)
density	1.126±0.06 g/cm3(Predicted)
refractive index	1.4780 to 1.4820
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
form	clear liquid
pka	4.67±0.20(Predicted)
color	Colorless to Almost colorless


Safety Information
Hazard Codes	C
Risk Statements	34
Safety Statements	26-36/37/39-45
RIDADR	UN 3265 8 / PGIII
HazardClass	8
PackingGroup	III
HS Code	2916200090


(S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID Usage And Synthesis
Uses	(S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.
Uses	(S)-3-Cyclohexene-1-carboxylic Acid has been used as a reactant for the preparation of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride, a potent and orally active direct inhibitor of factor Xa.
Synthesis	54.94 g of cyclohex-3-ene-1(S)-carboxylic acid (R)-(+)-methylbenzylamine salt and 18.2 volumes of H2O were charged to a flask at 20-25°C and stirred. To the mixture obtained further 6.7 volumes of H2O and 10 volumes of EtOAc were added. The mixture obtained was stirred for 15 min, the phases were separated and the organic layer was discarded. The aqueous layer was treated with 10 volumes of MTBE and 2.5 equivalents of 6M HCI were added slowly. The mixture obtained was stirred and two layers were formed, separated and the aqueous layer was extracted with MTBE. The organic layers obtained were combined and washed with aqueous, 30percent NaCl solution. The organic phase obtained was dried over Na2S04, filtered, and from the filtrate obtained solvent was removed in vacuo. Cyclohex-3-ene-1(S)-carboxylic acid in the form of a clear oil was obtained. Yield: 26.13 g (93.3percent of theory).


(S)-(-)-3-CYCLOHEXENECARBOXYLIC ACID Preparation Products And Raw materials
Raw materials	3-Cyclohexene-1-carboxylic acid, (1S)-, compd. with (αR)-α-methylbenzenemethanamine (1:1)-->3-Cyclohexenecarboxylic acid-->3-CYCLOHEXENE-1-CARBOXYLIC ACID METHYL ESTER
Preparation Products	Edoxaban Impurity 16

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