| Name | RN-1 dihydrochloride |
| Description | RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM). |
| In vitro | RN-1 dihydrochloride exhibits selectivity for LSD1 over MAO-A and MAO-B with IC50 values of 0.51 μM and 2.785 μM respectively[3]. |
| In vivo | In sickle cell disease (SCD) mice, RN-1 dihydrochloride (3-10 mg/kg; i.p.) effectively induces fetal hemoglobin (HbF) levels in red blood cells and reduces disease pathology[1]. In C57BL/6 male mice, after administration of RN-1 dihydrochloride (10 mg/kg, i.p.), concentrations are detectable up to 24 h post dose in both plasma and brain tissues. RN-1 dihydrochloride significantly impairs long-term memory, but not short-term memory. The brain/plasma exposure ratio is 88.9[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 18 mg/mL (39.79 mM), Sonication and heating to 60℃ are recommended.
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| Keywords | sickle | RN-1 Dihydrochloride | RN1 Dihydrochloride | RN1 dihydrochloride | RN-1 | RN1 | RN 1 Dihydrochloride | RN 1 dihydrochloride | RN 1 | MAO-B | MAO-A | LSD1 | irreversible | Inhibitor | inhibit | HistoneDemethylase | Histone Demethylase | hemoglobin | HbF | fetal | disease | cell | brain-penetrant |
| Inhibitors Related | Procaine | Hydralazine hydrochloride | Safinamide | Azure B | Paeonol | Hydroxylamine hydrochloride | Isatin | Furazolidone | Daminozide | Allylthiourea | Procaine hydrochloride | Eicosapentaenoic Acid |
| Related Compound Libraries | Histone Modification Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Anti-Alzheimer's Disease Compound Library | Epigenetics Compound Library | CNS-Penetrant Compound Library | Inhibitor Library | Mitochondria-Targeted Compound Library | Bioactive Compounds Library Max |
United States
