| Name | Risperidone |
| Description | Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent. |
| In vitro | In rats, Risperidone (0.5 mg/kg) results in diminished weight gain and enhanced UCP1 gene expression in BAT, along with elevated serum prolactin levels. At a dose of (0.05 mg/kg), Risperidone increases food intake and leptin gene expression in white adipose tissue without affecting the rate of weight gain. |
| In vivo | In activated microglia, Risperidone significantly inhibits the production of NO and pro-inflammatory cytokines. In Caco-2 cells, Risperidone (1-50 mM) notably enhances the intracellular accumulation of Rh123 by inhibiting the activity of P-gp, with an IC50 value of 5.87 mM. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 4.1 mg/mL (9.99 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.44 mM), Sonication is recommended.
Ethanol : 4.1 mg/mL (9.99 mM), Sonication is recommended.
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| Keywords | α2C-adrenergic receptor | Serotonin Receptor | Risperidone | P-gp (P-glycoprotein) | P-gp | Pgp | P-glycoprotein | Multidrug resistance protein 1 | MDR1 | Inhibitor | inhibit | DopamineReceptor | Dopamine Receptor | Dopamine | D3 | D2L | D2 | Cluster of differentiation 243 | CD243 | AdrenergicReceptor | Adrenergic Receptor | ABCB1 | 5-hydroxytryptamine Receptor | 5HTReceptor | 5-HT2A | 5-HT Receptor | 5HT Receptor |
| Inhibitors Related | Alverine citrate | Dapoxetine hydrochloride | Clozapine N-Oxide | Octopamine hydrochloride | Dexmedetomidine hydrochloride | D-Menthol | Citicoline | Oxolinic acid | Trazodone hydrochloride | Mianserin hydrochloride | Cinchonine | Cinchonidine |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library |
United States
