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ChemicalBook Product Catalog API Vitamins and Minerals medicines Vitamin B drugs Riboflavin

1/2

Riboflavin NEW

$0.20 1000KG

$6.00 1KG

Min. Order1KG
Purity99%
Cas No83-88-5
Supply Abilityg-kg-tons, free sample is available
Update time2024-03-29

Henan Fengda Chemical Co., Ltd

2YR

China

Since2023-02-10

AddressRoom 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro

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Chemical Properties

Product Name	Riboflavin
CAS No	83-88-5
EC-No
Min. Order	1KG
Purity	99%
Supply Ability	g-kg-tons, free sample is available
Release date	2024/03/29

1. Materials information

Names

Name	Riboflavin (B2)
Synonym	More Synonyms

Riboflavine Biological Activity

Description	Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.Target: OthersRiboflavin (vitamin B2) is the direct precursor of redox enzyme cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are essential for multiple cell physiology [1]. Urinary excretion of riboflavin contributes to one-half of the overall removal of riboflavin from plasma. No sex differences were observed for any of the pharmacokinetic variables (P > 0.05) [2]. Riboflavin, similar to other vitamins of the B complex, presents anti-inflammatory activity but its full characterization has not yet been carried out. Riboflavin (25, 50 or 100 mg/kg, i.p.), administered immediately and 2 h after the injection of carrageenan, induced antiedema and antinociceptive effects. The antinociceptive effect was not inhibited by the pretreatment with cadmium sulfate (1 mg/kg), an inhibitor of flavokinase. Riboflavin (50 or 100 mg/kg, i.p., 0 and 2 h) also inhibited the fever induced by lipopolysaccharide (LPS) in rats. Riboflavin is a safe drug, is approved for clinical use and exacerbates the antinociceptive effect of morphine, may warrant clinical trials to assess its potential in the treatment of different painful or inflammatory conditions [3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
References	[1]. Long, Q., et al., Riboflavin biosynthetic and regulatory factors as potential novel anti-infective drug targets. Chem Biol Drug Des, 2010. 75(4): p. 339-47. [2]. Zempleni, J., J.R. Galloway, and D.B. McCormick, Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans. Am J Clin Nutr, 1996. 63(1): p. 54-66. [3]. Bertollo, C.M., et al., Characterization of the antinociceptive and anti-inflammatory activities of riboflavin in different experimental models. Eur J Pharmacol, 2006. 547(1-3): p. 184-91.

Description

Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.Target: OthersRiboflavin (vitamin B2) is the direct precursor of redox enzyme cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are essential for multiple cell physiology [1]. Urinary excretion of riboflavin contributes to one-half of the overall removal of riboflavin from plasma. No sex differences were observed for any of the pharmacokinetic variables (P > 0.05) [2]. Riboflavin, similar to other vitamins of the B complex, presents anti-inflammatory activity but its full characterization has not yet been carried out. Riboflavin (25, 50 or 100 mg/kg, i.p.), administered immediately and 2 h after the injection of carrageenan, induced antiedema and antinociceptive effects. The antinociceptive effect was not inhibited by the pretreatment with cadmium sulfate (1 mg/kg), an inhibitor of flavokinase. Riboflavin (50 or 100 mg/kg, i.p., 0 and 2 h) also inhibited the fever induced by lipopolysaccharide (LPS) in rats. Riboflavin is a safe drug, is approved for clinical use and exacerbates the antinociceptive effect of morphine, may warrant clinical trials to assess its potential in the treatment of different painful or inflammatory conditions [3].

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Others

References

[1]. Long, Q., et al., Riboflavin biosynthetic and regulatory factors as potential novel anti-infective drug targets. Chem Biol Drug Des, 2010. 75(4): p. 339-47.

[2]. Zempleni, J., J.R. Galloway, and D.B. McCormick, Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans. Am J Clin Nutr, 1996. 63(1): p. 54-66.

[3]. Bertollo, C.M., et al., Characterization of the antinociceptive and anti-inflammatory activities of riboflavin in different experimental models. Eur J Pharmacol, 2006. 547(1-3): p. 184-91.

Chemical & Physical Properties

Density	1.7±0.1 g/cm3
Boiling Point	715.6±70.0 °C at 760 mmHg
Melting Point	290 °C (dec.)(lit.)
Molecular Formula	C17H20N4O6
Molecular Weight	376.364
Flash Point	386.6±35.7 °C
Exact Mass	376.138275
PSA	161.56000
LogP	-2.01
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.733
Storage condition	2~8°C
Water Solubility	0.07 g/L (20 ºC)

MSDS

Riboflavine MSDS(Chinese)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VJ1400000

CHEMICAL NAME :
Riboflavine

CAS REGISTRY NUMBER :
83-88-5

LAST UPDATED :
199701

DATA ITEMS CITED :
11

MOLECULAR FORMULA :
C17-H20-N4-O6

MOLECULAR WEIGHT :
376.41

WISWESSER LINE NOTATION :
T C666 BN DNVMV INJ B1YQYQYQ1Q L1 M1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
>10 gm/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
560 mg/kg

TOXIC EFFECTS :
Behavioral - food intake (animal) Kidney, Ureter, Bladder - urine volume decreased Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
5 gm/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
50 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD - Lethal dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Mammal - dog

DOSE/DURATION :
>2 gm/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Sex chromosome loss and nondisjunction

TEST SYSTEM :
Rodent - hamster Lung

DOSE/DURATION :
100 mg/L

REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 373,1,1997 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 67410 No. of Facilities: 1890 (estimated) No. of Industries: 8 No. of Occupations: 22 No. of Employees: 24319 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 67410 No. of Facilities: 2923 (estimated) No. of Industries: 15 No. of Occupations: 45 No. of Employees: 74790 (estimated) No. of Female Employees: 35023 (estimated)

Safety Information

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	F,T
Risk Phrases	11-23/24/25-39/23/24/25
Safety Phrases	S24/25
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	1
RTECS	VJ1400000
HS Code	2936230000

Synthetic Route

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Riboflavine

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Literature: Journal of the American Chemical Society, vol. 67, p. 2167 Journal of the American Chemical Society, , vol. 69, p. 1487,1491

Precursor & DownStream

Precursor 10	Previous 1/3 Next
CAS#:67-52-7 Barbituric acid CAS#:21037-26-3 (2R,3S,4S)-5-[(... CAS#:110-19-0 Isobutyl acetate CAS#:752-13-6 2',3',4',5'-...
DownStream 10	Previous 1/3 Next
CAS#:13345-95-4 1,5-dihydro-rib... CAS#:53-84-9 NAD+ CAS#:14985-41-2 riboflavin 5'-p... CAS#:20704-80-7 riboflavin-5'-m...

Customs

HS Code	2936230000
Summary	2936230000. unmixed vitaming b2 and deratives(whether or not dissolved in solvents). VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:4.0%. General tariff:20.0%

2. Packaging of materials

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.

Or smaller package 1kg/bottle, 10kgs/bottle as request.

3. Shipping & Delivery

By Express

Provide door to door service

Suitable for goods under 50kg

Delivery: 3-7 days

Cost: low cost

By Air

Provide airport to airport service

Suitable for goods over 50kg

Delivery: 3-14 days

Cost: high cost

By Sea

Provide seaport to seaport service

Suitable for goods over 100kg

Delivery: 2-45 days

Cost: low cost

4. Contact information

For more details, pls contact us freely.

Email address: Tina@fdachem.com

Mob: 86 15225627621

WhatsApp/Skype/Wechat/LINE: 86 15225627621

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Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.