| Name | Riboflavin Tetrabutyrate |
| Description | Riboflavin Tetrabutyrate, a lipophilic flavin derivative, possesses antioxidative and lipid peroxide-removing activities. |
| In vitro | Riboflavin Tetrabutyrate effectively suppresses NADPH-coupled and ascorbate-induced microsomal lipid peroxidation, also inhibiting oxygen uptake during such peroxidation. It appears to exert its antioxidative effects during or after the enzymic oxidation-reduction process, specifically after the abstraction of a hydrogen atom as a free radical from the active methylene group in polyunsaturated fatty acids[1]. |
| In vivo | Riboflavin Tetrabutyrate may enhance lipid metabolism in patients with atherosclerosis, diabetes, and fatty liver by inhibiting lipid peroxidation, resulting in decreased serum lipid levels. Prolonged administration increases hepatic 3-ketoacyl-CoA thiolase activity, promoting beta-oxidation of fatty acids in the liver, without affecting renal 3-ketoacyl-CoA thiolase, hepatic or renal acyl-CoA synthetase, and acyl-CoA dehydrogenase activities [1][2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (152.27 mM), Sonication is recommended.
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| Keywords | Riboflavin Tetrabutyrate | Riboflavin | ReactiveOxygenSpecies | Reactive Oxygen Species | Inhibitor | inhibit |
| Inhibitors Related | Sodium Thiocyanate | Acetylcysteine | Imeglimin hydrochloride | L-Ascorbic acid | Dimethyl fumarate | α-Vitamin E | Glucosamine | D-(+)-Glucono-1,5-lactone | Lycopene | L-Ascorbic acid sodium salt | Sodium 2-oxopropanoate | Naringenin |
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United States
