Retinyl acetate NEW

• DATA ITEMS CITED :

• 24

• MOLECULAR FORMULA :

• C22-H32-O2

• MOLECULAR WEIGHT :

• 328.54

• WISWESSER LINE NOTATION :

• L6UTJ A1 B1U1Y1&U2U1Y1&U2OV1 C1 C1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 4100 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intravenous

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 432 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 6352 ku/kg/13W-C

• TOXIC EFFECTS :

• Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 6347 mg/kg/21D-I

• TOXIC EFFECTS :

• Blood - changes in other cell count (unspecified) Blood - changes in platelet count Related to Chronic Data - death

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 2208 mg/kg/21D-I

• TOXIC EFFECTS :

• Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Blood - changes in platelet count

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 51800 mg/kg/2Y-C

• TOXIC EFFECTS :

• Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

• TYPE OF TEST :

• TD - Toxic dose (other than lowest)

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 95 gm/kg/2Y-C

• TOXIC EFFECTS :

• Tumorigenic - neoplastic by RTECS criteria Endocrine - thyroid tumors Skin and Appendages - tumors

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 480 mg/kg

• SEX/DURATION :

• female 6-19 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 310 mg/kg

• SEX/DURATION :

• female 10-12 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Effects on Embryo or Fetus - other effects to embryo

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 1377 mg/kg

• SEX/DURATION :

• female 15-19 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Specific Developmental Abnormalities - respiratory system

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 1377 mg/kg

• SEX/DURATION :

• female 15-19 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Effects on Newborn - stillbirth

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 826 mg/kg

• SEX/DURATION :

• female 12-15 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 1205 mg/kg

• SEX/DURATION :

• female 6-19 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

• TYPE OF TEST :

• TDLo - Lowest published toxic dose

• ROUTE OF EXPOSURE :

• Oral

• DOSE :

• 310 mg/kg

• SEX/DURATION :

• female 9-11 day(s) after conception

• TOXIC EFFECTS :

• Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

MUTATION DATA

• TYPE OF TEST :

• DNA inhibition

• TEST SYSTEM :

• Rodent - mouse Ascites tumor

• DOSE/DURATION :

• 100 umol/L

• REFERENCE :

• ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967- Volume(issue)/page/year: 44,356,1987 *** REVIEWS *** TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB-275-754 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80572 No. of Facilities: 277 (estimated) No. of Industries: 4 No. of Occupations: 11 No. of Employees: 5119 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80572 No. of Facilities: 550 (estimated) No. of Industries: 6 No. of Occupations: 20 No. of Employees: 13296 (estimated) No. of Female Employees: 7092 (estimated)