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Retinyl acetate

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Retinyl acetate Basic information
Retinyl acetate Chemical Properties
  • Melting point:57-58 °C
  • Boiling point:406.22°C (rough estimate)
  • Density 1.0474 (rough estimate)
  • refractive index 1.547-1.555
  • Flash point:14℃
  • storage temp. 2-8°C
  • solubility absolute ethanol: 25 mg/mL
  • form solid or viscous liquid
  • color Yellow powder
  • OdorAmine like
  • Water Solubility soluble
  • Sensitive Light & Air Sensitive & Hygroscopic
  • Merck 14,10013
  • BRN 1915439
  • InChIKeyQGNJRVVDBSJHIZ-QHLGVNSISA-N
  • CAS DataBase Reference127-47-9(CAS DataBase Reference)
  • NIST Chemistry ReferenceRetinol, acetate(127-47-9)
  • EPA Substance Registry SystemRetinol acetate (127-47-9)
Safety Information
MSDS
Retinyl acetate Usage And Synthesis
  • DescriptionRetinyl acetate (retinol acetate, vitamin A acetate) is a natural form of vitamin A. It is the acetate ester of retinol. It consists of yellow crystals which are greasy or sticky. It has a mild, characteristic odor. It has potential antineoplastic and chemo-preventive activities. It can be used to fortify food with vitamin A. As vitamin A acetate can induce cell differentiation and inhibit cell proliferation, it is used in skin-conditioning agent.
  • ReferenceVolker Bühler, Vademecum for Vitamin Formulations, 2001, ISBN 3-8047-1834-5
  • Chemical PropertiesCrystalline
  • Usesvitamin precursor
  • UsesEssential micronutrient
  • Safety ProfileModerately toxic by ingestion. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. See also VITAMIN A.
  • Purification MethodsThe acetate is separated from retinol by column chromatography, then crystallised from MeOH. [Kofler and Rubin Vitamins and Hormones (NY) 18 315 1960 for purification methods]. Store it in the dark, under N2 or Ar, at 0o. [Beilstein 6 IV 4135.]
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