| CAS: | 61-76-7 |
| MF: | C9H13NO2.ClH |
| MW: | 203.67 |
| EINECS: | 200-517-3 |
| Product Categories: | Adrenergic Agents;AFRIN;Amines;Aromatics;Chiral Reagents;API;Intermediates & Fine Chemicals;Pharmaceuticals;pharmaceutical raw material;Pharmaceutical intermediates;61-76-7 |
| Mol File: | 61-76-7.mol |
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| (R)-Phenylephrine Hydrochlorid Chemical Properties |
| Melting point | 143-145 °C(lit.) |
| alpha | -47 º (c=2, H2O) |
| refractive index | -45.5 ° (C=1, H2O) |
| Fp | 9℃ |
| storage temp. | 2-8°C |
| solubility | Freely soluble in water and in ethanol (96 per cent). |
| form | Crystalline Powder |
| pka | pK1 8.77; pK2 9.84(at 25℃) |
| color | White to almost white |
| PH | pH (10g/L, 25℃) : 4.5～5.5 |
| Water Solubility | >=10 g/100 mL at 21 ºC |
| Merck | 14,7286 |
| BRN | 4158948 |
| Stability: | Hygroscopic |
| LogP | -0.310 |
| CAS DataBase Reference | 61-76-7(CAS DataBase Reference) |
| EPA Substance Registry System | Phenylephrine hydrochloride (61-76-7) |
| (R)-Phenylephrine Hydrochlorid Usage And Synthesis |
| Description | R-(-)-Phenylephrine is an adrenergic α1A receptor agonist (Ki = 1.4 μM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 μM, respectively). By stimulating adrenergic α1 receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported relative affinity and potency values in rabbit are 5-fold weaker compared to that of L-norepinephrine . This compound is frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents. |
| Chemical Properties | Phenylephrine Hydrochloride is white or nearly white crystalline substance, odorless, bitter taste. Solutions are acid to litmus paper, freely soluble in water and in alcohol. Levorotatory in solution. |
| Chemical Properties | white to almost white crystalline powder |
| Originator | Neosynephrine, Badrial, France ,1953 |
| Uses | Phenylephrine hydrochloride is used medically as a vasoconstrictor and pressor drug. It is chemically related to epinephrine and ephedrine. Actions are usually longer lasting than the latter two drugs. The action of phenylephrine hydrochloride contrasts sharply with epinephrine and ephedrine, in that its action on the heart is to slow the rate and to increase the stroke output, inducing no disturbance in the rhythm of the pulse. In therapeutic doses, it produces little if any stimulation of either the spinal cord or cerebrum. The drug is intended for the maintenance of an adequate level of blood pressure during spinal and inhalation anesthesia and for the treatment of vascular failure in shock, shock-like states, and drug-induced hypotension, or hypersensitivity. It is also used to overcome paroxysmal supraventricular tachycardia, to prolong spinal anesthesia, and as a vasoconstrictor in regional analgesia. Caution is required in the administration of phenylephrine hydrochloride to elderly persons, or to patients with hyperthyroidism, bradycardia, partial heart block, myocardial disease, or severe arteriosclerosis. The brand name Neo-Synephrine? is also used to designate another product (nose drops) which does not contain phenylephrine hydrochloride. The nose drops contain xylometazoline hydrochloride. |
| Uses | DECONGESTANTS |
| Uses | (R)-Phenylephrine Hydrochloride is an α-Adrenergic agonist. Mydriatic; decongestant. |
| Definition | ChEBI: A hydrochloride that is the monohydrochloride salt of phenylephrine. |
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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