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ChemicalBook Product Catalog (R)-Equol

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(R)-Equol NEW

$35.00 2mg

$57.00 5mg

$97.00 10mg

Min. Order
Purity99.04%
Cas No221054-79-1
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

3YR

United States

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Chemical Properties

Product Name	(R)-Equol
CAS No	221054-79-1
EC-No
Min. Order
Purity	99.04%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	(R)-Equol
Description	(R)-Equol ((+)-Equol) is an ERα and ERβ agonist with Kis of 27.4 and 15.4 nM, respectively.
In vitro	(R)-Equol produced a dose-dependent inhibitory effect on the invasive ability of MDA-MB-231 cells, and this inhibitory effect was obvious at the highest test concentration (50 μM).Following 48-h exposure to (R)-Equol, invasion is reduced by 62% (p=0.009, versus untreated cells) with 50 μM (R)-Equol. Matrix metalloproteinase-2 (MMP-2) expression is significantly down-regulated following treatment with 50 μM (R)-Equol (p=0.035) [2].
In vivo	In animals, (R)-Equol significantly reduces the number of palpable tumors over time compared to controls (P=0.002). The number of palpable tumors per rat in the (R)-Equol-fed group is significantly lower than in rats treated with S-(-)equol (P=0.008). (R)-Equol-fed animals exhibit 43% fewer tumors than the control group, with this difference being highly statistically significant (P=0.004). The number of tumors per tumor-bearing animal is significantly lower in (R)-Equol-fed animals compared to controls (3.3±0.4 versus 5.5±0.5, P=0.004). At necropsy, the mean (±SEM) tumor weight per animal for (R)-Equol-fed rats (5.3±1.1 mg) is significantly reduced (P=0.04) compared to controls (9.9±1.4 mg). Feeding the (R)-Equol diet also results in significantly increased tumor latency (P=0.003) [3].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 100 mg/mL (412.76 mM), Sonication and heating are recommended.
Keywords	(R)-Equol \| (R) Equol \| Equol \| (R)Equol \| Inhibitor \| Estrogen Receptor/ERR \| inhibit
Inhibitors Related	Kaempferol \| Tamoxifen \| Mifepristone \| Estradiol \| Astragaloside IV \| Estradiol benzoate \| Melatonin \| Allura Red AC \| Natamycin \| Ethisterone
Related Compound Libraries	Nuclear Receptor Compound Library \| Bioactive Compound Library \| Endocrinology-Hormone Compound Library \| NO PAINS Compound Library \| Bioactive Compounds Library Max \| Human Metabolite Library

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