| Name | QNZ |
| Description | QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively. |
| In vitro | Intraperitoneal injection of EVP4593 (1 mg/kg) in rats suppressed carrageenan-induced paw edema in a dose-dependent manner. |
| In vivo | In murine spleen cells stimulated by lipopolysaccharide, EVP4593 (IC50= nM) inhibits the production of TNF-α. In rat neutrophils, EVP4593 (10 nM) suppresses the upregulation of CSE expression induced by lipopolysaccharide. EVP4593 (40 nM) entirely inhibits the increase in the number and length of axons during laminin treatment in Schwann cell adhesion. Additionally, in IB4-negative neurons, EVP4593 (100 nM) blocks the induction effect of GRO/KC on K currents. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble)
H2O : < 1 mg/mL (insoluble or slightly soluble)
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.81 mM), Sonication is recommended.
DMSO : 250 mg/mL (701.42 mM), Sonication is recommended.
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| Keywords | Tumor Necrosis Factor Receptor | TNF-α | TNFR | TNF Receptor | QNZ | Nuclear factor-κB | Nuclear factor-kappaB | NF-κB | NFκB | NF-kB | NFkB | Inhibitor | inhibit | EVP-4593 | EVP 4593 | CAY-10470 | CAY 10470 |
| Inhibitors Related | Kaolin | Chitin | Kojic acid | Uridine | Fumaric acid | 1,8-Cineole | 1,4-Naphthoquinone | Tributyrin | Glucosamine | Ethyl linoleate | N,N-Dimethylacetamide | Magnesium sulfate |
| Related Compound Libraries | Bioactive Compound Library | Anti-Alzheimer's Disease Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Angiogenesis related Compound Library | Neuroprotective Compound Library | Inhibitor Library | Immuno-Oncology Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Transcription Factor-Targeted Compound Library |
United States
