| Name | Protirelin Acetate |
| Description | Protirelin Acetate (TRH Acetate) is a thyrotropin-releasing hormone, stimulating the release of thyrotropin and prolactin from the anterior pituitary. |
| In vivo | Protirelin (TRH) is an ancient neuropeptide that emerged before the divergence of protostomes and deuterostomes, possibly playing a role in regulating postembryonic growth and reproduction[1]. This study explores Protirelin's impact on body temperature, administering intraperitoneal doses of 1, 5, 10, and 20 mg/kg to male Wistar rats weighing 200-250 g. The findings reveal a dose-dependent, temporary increase in body temperature following Protirelin administration. However, thyroidectomized rats injected with 20 mg/kg of Protirelin did not experience a temperature rise, unlike their sham-operated counterparts. These observations indicate that thyroid hormone release may contribute to Protirelin's hyperthermic effect[2]. |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.42 mM), Sonication is recommended.
H2O : 50 mg/mL (110.51 mM), Sonication is recommended.
|
| Keywords | TRH | Thyroidhormonereceptor(THR) | Thyroidhormonereceptor | Thyroid hormone receptor(THR) | Thyroid Hormone Receptor | Thyroid hormone receptor | Thyroid Hormone | THR | Protirelin Acetate | Protirelin | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite |
| Inhibitors Related | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | L-Methionine | Oleamide | Glycerol | Thymidine | Naringin | L-Ascorbic acid sodium salt | 3-Indoleacetic acid |
| Related Compound Libraries | Nuclear Receptor Compound Library | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Approved Drug Library | Drug Repurposing Compound Library | Peptide Compound Library | Endocrinology-Hormone Compound Library | FDA-Approved Drug Library | Bioactive Compounds Library Max |
United States
