| 名称 | Propylparaben |
| 描述 | Propylparaben (Propyl parahydroxybenzoate) is an antimicrobial agent, preservative, and flavoring agent. |
| 细胞实验 | Experimental conditions were as follows: a) basal recordings during which artificial cerebrospinal fluid (ACSF) (in mM: NaCl,125; KCl, 3; Na2HPO4, 1.25; NaHCO3, 25; MgCl2, 2; CaCl2, 2-D-(+)-glucose, 10; gassed with a mixture of 95% O2–5% CO2) was perfused; b) ACSF plus Propylparaben(PPB) (500 μM); c) 4-AP (100 μM) in Mg2+free-ACSF; d) 4-AP in Mg2+free-ACSF plus vehicle (dimethyl sulfoxide, DMSO at 0.04%); e) 4-AP in Mg2+free-ACSF plus drugs (phenytoin (PHT), 200 μM; PPB, 200 and 7500 μM). Each experimental condition lasted for 10 min. The onset of 4-AP-induced epileptiform activity was considered when bursts of 5 of more consecutive action potentials (APs) were present. The number of APs and excitatory postsynaptic potentials (EPSPs) greater than 1 mV and less than 10 mV of amplitude were quantified during periods of 5 min for each experimental condition[2] |
| 体外活性 | Propylparaben(PPB) suppressed the epileptiform activity in registered neurons.?This effect disappeared when PPB was removed from the solution of incubation.?PPB exerts an antiepileptic effect on CA1 pyramidal neurons in vitro.?Therefore, PPB may represent an effective antiepileptic compound[1]. propylparaben disrupts antral follicle growth and steroidogenic function by altering the cell-cycle, apoptosis, and steroidogenesis pathways[1]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 60 mg/mL (332.96 mM)
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| 关键字 | Endogenous Metabolite | Inhibitor | inhibit | Apoptosis | Propylparaben | Bacterial |
| 相关产品 | Sucrose | Neomycin sulfate | Glycerol | Dimethyl sulfoxide |
| 相关库 | 抗癌天然产物库 | 经典已知活性库 | 天然产物库 | 烟草单体化合物库 | 抗癌上市药物库 | 化妆品成分化合物库 | 已知活性化合物库 |
United States
