Propylene Glycol (PG) NEW

Propylene glycol has good solubility, less toxicity and irritation, and is widely used as a solvent, extraction solvent and preservative for injections (such as intramuscular injections, intravenous injections) and non-injectable pharmaceutical preparations (such as oral liquid, eye preparations, ear preparations, dental preparations, rectal and vaginal preparations, transdermal preparations, etc.). It is a better solvent than glycerin. It can dissolve many substances such as corticosterols (sex hormones), chloramphenicol, sulfonamides, barbiturates, hemopine, quinidine, dehydrocorticosterone acetate, fumarine sulfate, nitrogen mustard hydrochloride, vitamin A, vitamin D, many volatile oils, most alkaloids, and many local anesthetics. As a bacteriostatic agent, propylene glycol is similar to ethanol, and the effect of inhibiting mold is similar to glycerin, slightly lower than ethanol. Propylene glycol is commonly used as a plasticizer for water-based film coating materials. The same amount of mixed liquid with water can delay the hydrolysis of some drugs and increase the stability of preparation products. 15% ~ 30% of propylene glycol solution and semi-solid preparation can be used as antibacterial preservatives, about 15% of propylene glycol topical preparation can be used as moisturizing agent, 10% ~ 30% of propylene glycol aerosol solvent, 10% ~ 25% of propylene glycol oral solution, 10% ~ 60% of injection preparation, 5% ~ 80% of local preparation should be used as solvent and co-solvent.