| Name | Proguanil hydrochloride |
| Description | Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite. |
| Cell Research | Sertoli cells obtained from sixteen to eighteen day-old-rats are cultured and treated with 0.3 μM to 10 μM of proguanil for 5 days after which Sertoli cell viability and nuclei integrity are determined. Also, the genetic expressions of transferrin and Glial cell line-derived neurotrophic factor are assessed. They are for reference only. |
| Animal Research | Proguanil is prepared in distilled water.Rats: Groups of ten to twelve-week-old rats are administered proguanil (2.9 mg/kg body weight) daily for 5 days and 6 weeks respectively. Thereafter, body and reproductive organ weights are taken, sperm parameters are analyzed, while the histology of the testis and epididymis are carried out. Also, serum levels of testosterone, luteinizing hormone and follicle stimulating hormone are determined. They are for reference only. |
| In vitro | proguanil appeared to be a substrate of OCT1 and OCT2 with affinities of 8.1 and 9.0 μM, respectively |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 55 mg/mL (189.53 mM), Sonication is recommended.
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| Keywords | toxicity | thymidylate synthase | RNASynthesis | RNA Synthesis | reproductive | Proguanil hydrochloride | Proguanil Hydrochloride | Proguanil | Parasite | Paludrine Hydrochloride | NADH dehydrogenase | Inhibitor | inhibit | infection | embryotoxicity | DNASynthesis | DNA Synthesis | dihydrofolate reductase | Chlorguanide Hydrochloride | biguanide | antimalarial | Antifolate |
| Inhibitors Related | 5-Fluorouracil | Kaempferol | Procaine | Kojic acid | Urethane | Hydroxychloroquine | Guanidine hydrochloride | Metronidazole | Methotrexate disodium | Nitazoxanide | Doxycycline | Thymidine |
| Related Compound Libraries | Anti-Parasitic Compound Library | Bioactive Compound Library | ReFRAME Related Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
United States
