| Name | PROCYANIDIN C1 |
| Description | Procyanidin C1 is a natural polyphenol that causes DNA damage, cell cycle arrest, and apoptosis induction. It reduces Bcl-2 protein levels and enhances the expression of BAX, caspase 3, and 9 in cancer cells. |
| In vitro | METHODS: PSC27 cells were treated with Procyanidin C1 (5, 10, 25, 50, 100, 400 μM) and senescent PSC27 cell survival was measured by SA-β-Gal staining.
RESULTS Procyanidin C1 exerted an anti-senescent effect on senescent stromal cells starting at a concentration of 50 μM, at which concentration proliferating cells were largely unaffected. [1]
METHODS: Procyanidin C1 (5 and 10 μM) was used in DLD1 and HCT116 cells, and the expression of has-miR-501-3p was detected.
RESULTS Procyanidin C1 inhibited the expression of has-miR-501-3p in CRC cells with increasing concentrations. [4] |
| In vivo | METHODS: DLD1 and SW1463 cells were injected into the right axilla of BALB/c nude mice. The nude mice were treated with Procyanidin C1 (20 mg/kg and 40 mg/kg, intraperitoneal injection, once every three days), and the tumor volume and tumor weight were calculated.
METHODS: Procyanidin C1 can inhibit tumor growth and metastasis in CRC, and the has-miR-501-3p/HIGD1A axis is involved in this process. [4] |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 90.14 mg/mL (104 mM), Sonication and heating are recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (3.81 mM), Sonication is recommended.
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| Keywords | PROCYANIDIN C-1 | PROCYANIDIN C1 | Procyanidin C 1 | PCC-1 | PCC1 | PCC 1 | Inhibitor | inhibit | Apoptosis protein | Apoptosis |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Flubendazole | Cysteamine hydrochloride | L-Glutamic acid monosodium salt monohydrate | Sodium 4-phenylbutyrate | L-Ascorbic acid | L-Glutamic acid | Tributyrin | L-Ascorbic acid sodium salt | Alginic acid | Dextran sulfate sodium salt (MW 5000) |
| Related Compound Libraries | Polyphenolic Natural Product Library | Flavonoid Natural Product Library | Traditional Chinese Medicine Monomer Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library for HTS | Bitter Compound library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Anti-Cancer Active Compound Library | Food as Medicine Compound Library |
United States
