Chinese name: Procaine hydrochloride
English name: Procaine hydrochloride
CAS: 51-05-8
EINECS number: 200-077-2
Molecular formula: C13H21ClN2O2
MDL number: MFCD00007893
Molecular weight: 272.77
Appearance: White crystal or crystalline powder, odorless, slightly bitter taste, followed by paralysis. This product is easily soluble in water, slightly soluble in ethanol, slightly soluble in chloroform, insoluble in ether.
Melting point: 155-156 °C(lit.)
Boiling point: 195-196°C 17mm
Density: 1.1761 (rough estimate)
Refractive index: 1.5270 (estimate)
Flash point: 195-196°C/17mm
Storage condition: room temp
Solubility: Solution S is clear (2.2.1) and colourless (2.2.2, Method II).
Form crystal or crystalline powder
Color colorless to white
Water soluble Soluble in water
Sensitivity air sensitivity
Merck14, 7757
BRN3917802
Stable and stable. Incompatible with strong oxidants.
InChIKeyHCBIBCJNVBAKAB-UHFFFAOYSA-N
LogP2.364 (est)
Use 1
Na+ channel blockers or sealers.
intro
Procaine hydrochloride is a local anesthetic, can temporarily block the conduction of nerve fibers and has anesthetic effect, strong effect, low toxicity, and no addiction, but the penetration of skin and mucous membrane is weak, not suitable for surface anesthesia, clinical mainly used for infiltration, spinal and conduction anesthesia.
The aqueous solution of this product is stable between pH3.0 and 5.0. Therefore, when preparing procaine hydrochloride injection, it is generally necessary to add acid to adjust the pH3.3 ~ 5.5, and strictly control the sterilization temperature and time, and it is appropriate to sterilize the steam at 100℃ for 30min, and attention should be paid to shade the light and keep it closed. The aromatic amino group in the structure of this product is combined with sodium nitrite to form diazo salt in dilute hydrochloric acid, and basic β-naphthol is added to produce scarlet azo compound.
nature
Procaine hydrochloride is white fine needle crystal or crystalline powder at room temperature, odorless, slightly bitter and hemp, easily soluble in water, soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether. The ester bond in the structure of procaine hydrochloride can be hydrolyzed to produce p-aminobenzoic acid and diethylaminoethanol. Under certain conditions, p-aminobenzoic acid can be further decarboxylated to produce toxic aniline. The structure of procaine hydrochloride has aromatic amino group, easy oxidation discoloration, pH value, temperature, ultraviolet light, oxygen and metal ions can accelerate oxidation discoloration.
China
